dc.contributor.author | Agha, Golareh | en_US |
dc.contributor.author | Hajj, Hanine | en_US |
dc.contributor.author | Rifas-Shiman, Sheryl L. | en_US |
dc.contributor.author | Just, Allan C. | en_US |
dc.contributor.author | Hivert, Marie-France | en_US |
dc.contributor.author | Burris, Heather H. | en_US |
dc.contributor.author | Lin, Xihong | en_US |
dc.contributor.author | Litonjua, Augusto A. | en_US |
dc.contributor.author | Oken, Emily | en_US |
dc.contributor.author | DeMeo, Dawn L. | en_US |
dc.contributor.author | Gillman, Matthew W. | en_US |
dc.contributor.author | Baccarelli, Andrea A. | en_US |
dc.date.accessioned | 2016-12-02T15:25:46Z | |
dc.date.issued | 2016 | en_US |
dc.identifier.citation | Agha, G., H. Hajj, S. L. Rifas-Shiman, A. C. Just, M. Hivert, H. H. Burris, X. Lin, et al. 2016. “Birth weight-for-gestational age is associated with DNA methylation at birth and in childhood.” Clinical Epigenetics 8 (1): 118. doi:10.1186/s13148-016-0285-3. http://dx.doi.org/10.1186/s13148-016-0285-3. | en |
dc.identifier.issn | 1868-7075 | en |
dc.identifier.uri | http://nrs.harvard.edu/urn-3:HUL.InstRepos:29626177 | |
dc.description.abstract | Background: Both higher and lower fetal growth are associated with cardio-metabolic health later in life, suggesting that prenatal developmental programming determines long-term cardiovascular disease risk. Epigenetic mechanisms, which orchestrate fetal growth and development, may offer insight on the early programming of health and disease. We investigated whether birth weight-for-gestational is associated with DNA methylation at birth and mid-childhood, measured via the Infinium 450K array. Methods/results Participants were from Project Viva, a pre-birth cohort of pregnant women and their children in Eastern Massachusetts. After exclusion of participants with maternal type 1 or 2 diabetes and gestational age <34 weeks, we used DNA methylation assays from 476 venous umbilical cord blood samples and a subset of 235 who additionally had peripheral blood samples available in mid-childhood (age 7–10 years). Among 392,918 CpG sites analyzed, birth weight-for-gestational age z-score was associated with cord blood DNA methylation at 34 CpGs (false discovery rate P < 0.05), after adjusting for maternal age, race/ethnicity, education, smoking, parity, delivery mode, pre-pregnancy BMI, gestational diabetes status, child sex, and estimated cord blood cell proportions based on a cord blood reference panel. Two of these CpGs were previously reported in epigenome-wide analyses of birth weight, and several other CpGs map to genes relevant to fetal growth and development. Namely, higher birth weight-for-gestational age was associated with higher methylation at four CpGs at the PBX1 locus (e.g., β (95% CI) for lead signal at cg06750897 = 1.9 (1.2, 2.6)), which encodes a transcription factor that regulates embryonic development. Birth weight-for-gestational age was also associated with mid-childhood blood DNA methylation at four of the 34 CpGs identified in cord blood analyses, including sites at the PBX1 locus described. Conclusions: We identified CpG sites where birth weight-for-gestational age was associated with DNA methylation at birth, and for a subset of these sites, birth weight-for-gestational age was also associated with DNA methylation at mid-childhood. Electronic supplementary material The online version of this article (doi:10.1186/s13148-016-0285-3) contains supplementary material, which is available to authorized users. | en |
dc.language.iso | en_US | en |
dc.publisher | BioMed Central | en |
dc.relation.isversionof | doi:10.1186/s13148-016-0285-3 | en |
dc.relation.hasversion | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5112715/pdf/ | en |
dash.license | LAA | en_US |
dc.subject | Epigenetics | en |
dc.subject | DNA methylation | en |
dc.subject | Birth weight | en |
dc.title | Birth weight-for-gestational age is associated with DNA methylation at birth and in childhood | en |
dc.type | Journal Article | en_US |
dc.description.version | Version of Record | en |
dc.relation.journal | Clinical Epigenetics | en |
dash.depositing.author | Rifas-Shiman, Sheryl L. | en_US |
dc.date.available | 2016-12-02T15:25:46Z | |
dc.identifier.doi | 10.1186/s13148-016-0285-3 | * |
dash.authorsordered | false | |
dash.contributor.affiliated | Hivert, Marie-France | |
dash.contributor.affiliated | Rifas-Shiman, Sheryl | |
dash.contributor.affiliated | Oken, Emily | |
dash.contributor.affiliated | Litonjua, Augusto A. | |
dash.contributor.affiliated | Burris, Heather H. | |
dash.contributor.affiliated | Gillman, Matthew | |
dash.contributor.affiliated | Demeo, Dawn | |
dash.contributor.affiliated | Lin, Xihong | |
dc.identifier.orcid | 0000-0003-2513-3339 | |