Neuroendocrine modulation sustains the C. elegans forward motor state
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Author
Lim, Maria A
Chitturi, Jyothsna
Laskova, Valeriya
Meng, Jun
Findeis, Daniel
Wiekenberg, Anne
Mulcahy, Ben
Luo, Linjiao
Li, Yan
Lu, Yangning
Hung, Wesley
Qu, Yixin
Ho, Chi-Yip
Holmyard, Douglas
McWhirter, Rebecca
Miller, David M
Schnabel, Ralf
Zhen, Mei
Note: Order does not necessarily reflect citation order of authors.
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https://doi.org/10.7554/eLife.19887Metadata
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Lim, M. A., J. Chitturi, V. Laskova, J. Meng, D. Findeis, A. Wiekenberg, B. Mulcahy, et al. 2016. “Neuroendocrine modulation sustains the C. elegans forward motor state.” eLife 5 (1): e19887. doi:10.7554/eLife.19887. http://dx.doi.org/10.7554/eLife.19887.Abstract
Neuromodulators shape neural circuit dynamics. Combining electron microscopy, genetics, transcriptome profiling, calcium imaging, and optogenetics, we discovered a peptidergic neuron that modulates C. elegans motor circuit dynamics. The Six/SO-family homeobox transcription factor UNC-39 governs lineage-specific neurogenesis to give rise to a neuron RID. RID bears the anatomic hallmarks of a specialized endocrine neuron: it harbors near-exclusive dense core vesicles that cluster periodically along the axon, and expresses multiple neuropeptides, including the FMRF-amide-related FLP-14. RID activity increases during forward movement. Ablating RID reduces the sustainability of forward movement, a phenotype partially recapitulated by removing FLP-14. Optogenetic depolarization of RID prolongs forward movement, an effect reduced in the absence of FLP-14. Together, these results establish the role of a neuroendocrine cell RID in sustaining a specific behavioral state in C. elegans. DOI: http://dx.doi.org/10.7554/eLife.19887.001Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5120884/pdf/Terms of Use
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