A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape
View/ Open
Author
Ried, Janina S.
Jeff M., Janina
Chu, Audrey Y.
Bragg-Gresham, Jennifer L.
van Dongen, Jenny
Huffman, Jennifer E.
Ahluwalia, Tarunveer S.
Cadby, Gemma
Eklund, Niina
Eriksson, Joel
Feitosa, Mary F.
Goel, Anuj
Gorski, Mathias
Hayward, Caroline
Heard-Costa, Nancy L.
Jackson, Anne U.
Jokinen, Eero
Kanoni, Stavroula
Kristiansson, Kati
Kutalik, Zoltán
Lahti, Jari
Luan, Jian'an
Mägi, Reedik
Mahajan, Anubha
Mangino, Massimo
Medina-Gomez, Carolina
Monda, Keri L.
Nolte, Ilja M.
Pérusse, Louis
Prokopenko, Inga
Rose, Lynda M.
Salvi, Erika
Smith, Megan T.
Snieder, Harold
Stančáková, Alena
Ju Sung, Yun
Tachmazidou, Ioanna
Teumer, Alexander
Thorleifsson, Gudmar
van der Harst, Pim
Walker, Ryan W.
Wang, Sophie R.
Wild, Sarah H.
Willems, Sara M.
Wong, Andrew
Zhang, Weihua
Albrecht, Eva
Couto Alves, Alexessander
Bakker, Stephan J. L.
Barlassina, Cristina
Bartz, Traci M.
Beilby, John
Bellis, Claire
Bergman, Richard N.
Bergmann, Sven
Blangero, John
Blüher, Matthias
Boerwinkle, Eric
Bonnycastle, Lori L.
Bornstein, Stefan R.
Bruinenberg, Marcel
Campbell, Harry
Chen, Yii-Der Ida
Chiang, Charleston W. K.
Chines, Peter S.
Collins, Francis S
Cucca, Fracensco
Cupples, L Adrienne
D'Avila, Francesca
de Geus, Eco J .C.
Dedoussis, George
Dimitriou, Maria
Döring, Angela
Eriksson, Johan G.
Farmaki, Aliki-Eleni
Farrall, Martin
Ferreira, Teresa
Fischer, Krista
Forouhi, Nita G.
Friedrich, Nele
Gjesing, Anette Prior
Glorioso, Nicola
Graff, Mariaelisa
Grallert, Harald
Grarup, Niels
Gräßler, Jürgen
Grewal, Jagvir
Hamsten, Anders
Harder, Marie Neergaard
Hartman, Catharina A.
Hassinen, Maija
Hastie, Nicholas
Hattersley, Andrew Tym
Havulinna, Aki S.
Heliövaara, Markku
Hillege, Hans
Hofman, Albert
Holmen, Oddgeir
Homuth, Georg
Hottenga, Jouke-Jan
Hui, Jennie
Husemoen, Lise Lotte
Hysi, Pirro G.
Isaacs, Aaron
Ittermann, Till
Jalilzadeh, Shapour
James, Alan L.
Jørgensen, Torben
Jousilahti, Pekka
Jula, Antti
Marie Justesen, Johanne
Justice, Anne E.
Kähönen, Mika
Karaleftheri, Maria
Tee Khaw, Kay
Keinanen-Kiukaanniemi, Sirkka M.
Kinnunen, Leena
Knekt, Paul B.
Koistinen, Heikki A.
Kolcic, Ivana
Kooner, Ishminder K.
Koskinen, Seppo
Kovacs, Peter
Kyriakou, Theodosios
Laitinen, Tomi
Langenberg, Claudia
Lewin, Alexandra M.
Lichtner, Peter
Lindgren, Cecilia M.
Lindström, Jaana
Linneberg, Allan
Lorbeer, Roberto
Lorentzon, Mattias
Luben, Robert
Lyssenko, Valeriya
Männistö, Satu
Manunta, Paolo
Leach, Irene Mateo
McArdle, Wendy L.
Mcknight, Barbara
Mohlke, Karen L.
Mihailov, Evelin
Milani, Lili
Mills, Rebecca
Montasser, May E.
Morris, Andrew P.
Müller, Gabriele
Musk, Arthur W.
Narisu, Narisu
Ong, Ken K.
Oostra, Ben A.
Osmond, Clive
Pankow, James S.
Paternoster, Lavinia
Penninx, Brenda W.
Pichler, Irene
Pilia, Maria G.
Polašek, Ozren
Pramstaller, Peter P.
Raitakari, Olli T
Rankinen, Tuomo
Rao, D. C.
Rayner, Nigel W.
Ribel-Madsen, Rasmus
Rice, Treva K.
Richards, Marcus
Rivadeneira, Fernando
Ryan, Kathy A.
Sanna, Serena
Sarzynski, Mark A.
Scholtens, Salome
Scott, Robert A.
Sebert, Sylvain
Southam, Lorraine
Sparsø, Thomas Hempel
Steinthorsdottir, Valgerdur
Stirrups, Kathleen
Stolk, Ronald P.
Strauch, Konstantin
Stringham, Heather M.
Swertz, Morris A.
Swift, Amy J.
Tönjes, Anke
Tsafantakis, Emmanouil
van der Most, Peter J.
Van Vliet-Ostaptchouk, Jana V.
Vandenput, Liesbeth
Vartiainen, Erkki
Venturini, Cristina
Verweij, Niek
Viikari, Jorma S.
Vitart, Veronique
Vohl, Marie-Claude
Vonk, Judith M.
Waeber, Gérard
Widén, Elisabeth
Willemsen, Gonneke
Wilsgaard, Tom
Winkler, Thomas W.
Wright, Alan F.
Yerges-Armstrong, Laura M.
Hua Zhao, Jing
Carola Zillikens, M.
Boomsma, Dorret I.
Bouchard, Claude
Chambers, John C.
Cusi, Daniele
Gansevoort, Ron T.
Gieger, Christian
Hansen, Torben
Hicks, Andrew A.
Hveem, Kristian
Jarvelin, Marjo-Riitta
Kajantie, Eero
Kooner, Jaspal S.
Kuh, Diana
Kuusisto, Johanna
Laakso, Markku
Lakka, Timo A.
Lehtimäki, Terho
Metspalu, Andres
Njølstad, Inger
Ohlsson, Claes
Oldehinkel, Albertine J.
Palmer, Lyle J.
Pedersen, Oluf
Perola, Markus
Peters, Annette
Psaty, Bruce M.
Puolijoki, Hannu
Rauramaa, Rainer
Rudan, Igor
Salomaa, Veikko
Schwarz, Peter E. H.
Shudiner, Alan R.
Smit, Jan H.
Sørensen, Thorkild I. A.
Spector, Timothy D.
Stefansson, Kari
Stumvoll, Michael
Tremblay, Angelo
Tuomilehto, Jaakko
Uitterlinden, André G.
Uusitupa, Matti
Völker, Uwe
Vollenweider, Peter
Wareham, Nicholas J.
Watkins, Hugh
Wilson, James F.
Zeggini, Eleftheria
Abecasis, Goncalo R.
Boehnke, Michael
Borecki, Ingrid B.
Deloukas, Panos
van Duijn, Cornelia M.
Groop, Leif C.
Heid, Iris M.
Kaplan, Robert C.
McCarthy, Mark I.
North, Kari E.
O'Connell, Jeffrey R.
Schlessinger, David
Thorsteinsdottir, Unnur
Strachan, David P.
Frayling, Timothy
Müller-Nurasyid, Martina
Loos, Ruth J. F.
Note: Order does not necessarily reflect citation order of authors.
Published Version
https://doi.org/10.1038/ncomms13357Metadata
Show full item recordCitation
Ried, J. S., J. Jeff M., A. Y. Chu, J. L. Bragg-Gresham, J. van Dongen, J. E. Huffman, T. S. Ahluwalia, et al. 2016. “A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape.” Nature Communications 7 (1): 13357. doi:10.1038/ncomms13357. http://dx.doi.org/10.1038/ncomms13357.Abstract
Large consortia have revealed hundreds of genetic loci associated with anthropometric traits, one trait at a time. We examined whether genetic variants affect body shape as a composite phenotype that is represented by a combination of anthropometric traits. We developed an approach that calculates averaged PCs (AvPCs) representing body shape derived from six anthropometric traits (body mass index, height, weight, waist and hip circumference, waist-to-hip ratio). The first four AvPCs explain >99% of the variability, are heritable, and associate with cardiometabolic outcomes. We performed genome-wide association analyses for each body shape composite phenotype across 65 studies and meta-analysed summary statistics. We identify six novel loci: LEMD2 and CD47 for AvPC1, RPS6KA5/C14orf159 and GANAB for AvPC3, and ARL15 and ANP32 for AvPC4. Our findings highlight the value of using multiple traits to define complex phenotypes for discovery, which are not captured by single-trait analyses, and may shed light onto new pathways.Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5114527/pdf/Terms of Use
This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAACitable link to this page
http://nrs.harvard.edu/urn-3:HUL.InstRepos:29626223
Collections
- HMS Scholarly Articles [17922]
- SPH Scholarly Articles [6362]
Contact administrator regarding this item (to report mistakes or request changes)