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dc.contributor.authorRied, Janina S.en_US
dc.contributor.authorJeff M., Janinaen_US
dc.contributor.authorChu, Audrey Y.en_US
dc.contributor.authorBragg-Gresham, Jennifer L.en_US
dc.contributor.authorvan Dongen, Jennyen_US
dc.contributor.authorHuffman, Jennifer E.en_US
dc.contributor.authorAhluwalia, Tarunveer S.en_US
dc.contributor.authorCadby, Gemmaen_US
dc.contributor.authorEklund, Niinaen_US
dc.contributor.authorEriksson, Joelen_US
dc.contributor.authorEsko, Tõnuen_US
dc.contributor.authorFeitosa, Mary F.en_US
dc.contributor.authorGoel, Anujen_US
dc.contributor.authorGorski, Mathiasen_US
dc.contributor.authorHayward, Carolineen_US
dc.contributor.authorHeard-Costa, Nancy L.en_US
dc.contributor.authorJackson, Anne U.en_US
dc.contributor.authorJokinen, Eeroen_US
dc.contributor.authorKanoni, Stavroulaen_US
dc.contributor.authorKristiansson, Katien_US
dc.contributor.authorKutalik, Zoltánen_US
dc.contributor.authorLahti, Jarien_US
dc.contributor.authorLuan, Jian'anen_US
dc.contributor.authorMägi, Reediken_US
dc.contributor.authorMahajan, Anubhaen_US
dc.contributor.authorMangino, Massimoen_US
dc.contributor.authorMedina-Gomez, Carolinaen_US
dc.contributor.authorMonda, Keri L.en_US
dc.contributor.authorNolte, Ilja M.en_US
dc.contributor.authorPérusse, Louisen_US
dc.contributor.authorProkopenko, Ingaen_US
dc.contributor.authorQi, Luen_US
dc.contributor.authorRose, Lynda M.en_US
dc.contributor.authorSalvi, Erikaen_US
dc.contributor.authorSmith, Megan T.en_US
dc.contributor.authorSnieder, Harolden_US
dc.contributor.authorStančáková, Alenaen_US
dc.contributor.authorJu Sung, Yunen_US
dc.contributor.authorTachmazidou, Ioannaen_US
dc.contributor.authorTeumer, Alexanderen_US
dc.contributor.authorThorleifsson, Gudmaren_US
dc.contributor.authorvan der Harst, Pimen_US
dc.contributor.authorWalker, Ryan W.en_US
dc.contributor.authorWang, Sophie R.en_US
dc.contributor.authorWild, Sarah H.en_US
dc.contributor.authorWillems, Sara M.en_US
dc.contributor.authorWong, Andrewen_US
dc.contributor.authorZhang, Weihuaen_US
dc.contributor.authorAlbrecht, Evaen_US
dc.contributor.authorCouto Alves, Alexessanderen_US
dc.contributor.authorBakker, Stephan J. L.en_US
dc.contributor.authorBarlassina, Cristinaen_US
dc.contributor.authorBartz, Traci M.en_US
dc.contributor.authorBeilby, Johnen_US
dc.contributor.authorBellis, Claireen_US
dc.contributor.authorBergman, Richard N.en_US
dc.contributor.authorBergmann, Svenen_US
dc.contributor.authorBlangero, Johnen_US
dc.contributor.authorBlüher, Matthiasen_US
dc.contributor.authorBoerwinkle, Ericen_US
dc.contributor.authorBonnycastle, Lori L.en_US
dc.contributor.authorBornstein, Stefan R.en_US
dc.contributor.authorBruinenberg, Marcelen_US
dc.contributor.authorCampbell, Harryen_US
dc.contributor.authorChen, Yii-Der Idaen_US
dc.contributor.authorChiang, Charleston W. K.en_US
dc.contributor.authorChines, Peter S.en_US
dc.contributor.authorCollins, Francis Sen_US
dc.contributor.authorCucca, Fracenscoen_US
dc.contributor.authorCupples, L Adrienneen_US
dc.contributor.authorD'Avila, Francescaen_US
dc.contributor.authorde Geus, Eco J .C.en_US
dc.contributor.authorDedoussis, Georgeen_US
dc.contributor.authorDimitriou, Mariaen_US
dc.contributor.authorDöring, Angelaen_US
dc.contributor.authorEriksson, Johan G.en_US
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dc.contributor.authorFerreira, Teresaen_US
dc.contributor.authorFischer, Kristaen_US
dc.contributor.authorForouhi, Nita G.en_US
dc.contributor.authorFriedrich, Neleen_US
dc.contributor.authorGjesing, Anette Prioren_US
dc.contributor.authorGlorioso, Nicolaen_US
dc.contributor.authorGraff, Mariaelisaen_US
dc.contributor.authorGrallert, Haralden_US
dc.contributor.authorGrarup, Nielsen_US
dc.contributor.authorGräßler, Jürgenen_US
dc.contributor.authorGrewal, Jagviren_US
dc.contributor.authorHamsten, Andersen_US
dc.contributor.authorHarder, Marie Neergaarden_US
dc.contributor.authorHartman, Catharina A.en_US
dc.contributor.authorHassinen, Maijaen_US
dc.contributor.authorHastie, Nicholasen_US
dc.contributor.authorHattersley, Andrew Tymen_US
dc.contributor.authorHavulinna, Aki S.en_US
dc.contributor.authorHeliövaara, Markkuen_US
dc.contributor.authorHillege, Hansen_US
dc.contributor.authorHofman, Alberten_US
dc.contributor.authorHolmen, Oddgeiren_US
dc.contributor.authorHomuth, Georgen_US
dc.contributor.authorHottenga, Jouke-Janen_US
dc.contributor.authorHui, Jennieen_US
dc.contributor.authorHusemoen, Lise Lotteen_US
dc.contributor.authorHysi, Pirro G.en_US
dc.contributor.authorIsaacs, Aaronen_US
dc.contributor.authorIttermann, Tillen_US
dc.contributor.authorJalilzadeh, Shapouren_US
dc.contributor.authorJames, Alan L.en_US
dc.contributor.authorJørgensen, Torbenen_US
dc.contributor.authorJousilahti, Pekkaen_US
dc.contributor.authorJula, Anttien_US
dc.contributor.authorMarie Justesen, Johanneen_US
dc.contributor.authorJustice, Anne E.en_US
dc.contributor.authorKähönen, Mikaen_US
dc.contributor.authorKaraleftheri, Mariaen_US
dc.contributor.authorTee Khaw, Kayen_US
dc.contributor.authorKeinanen-Kiukaanniemi, Sirkka M.en_US
dc.contributor.authorKinnunen, Leenaen_US
dc.contributor.authorKnekt, Paul B.en_US
dc.contributor.authorKoistinen, Heikki A.en_US
dc.contributor.authorKolcic, Ivanaen_US
dc.contributor.authorKooner, Ishminder K.en_US
dc.contributor.authorKoskinen, Seppoen_US
dc.contributor.authorKovacs, Peteren_US
dc.contributor.authorKyriakou, Theodosiosen_US
dc.contributor.authorLaitinen, Tomien_US
dc.contributor.authorLangenberg, Claudiaen_US
dc.contributor.authorLewin, Alexandra M.en_US
dc.contributor.authorLichtner, Peteren_US
dc.contributor.authorLindgren, Cecilia M.en_US
dc.contributor.authorLindström, Jaanaen_US
dc.contributor.authorLinneberg, Allanen_US
dc.contributor.authorLorbeer, Robertoen_US
dc.contributor.authorLorentzon, Mattiasen_US
dc.contributor.authorLuben, Roberten_US
dc.contributor.authorLyssenko, Valeriyaen_US
dc.contributor.authorMännistö, Satuen_US
dc.contributor.authorManunta, Paoloen_US
dc.contributor.authorLeach, Irene Mateoen_US
dc.contributor.authorMcArdle, Wendy L.en_US
dc.contributor.authorMcknight, Barbaraen_US
dc.contributor.authorMohlke, Karen L.en_US
dc.contributor.authorMihailov, Evelinen_US
dc.contributor.authorMilani, Lilien_US
dc.contributor.authorMills, Rebeccaen_US
dc.contributor.authorMontasser, May E.en_US
dc.contributor.authorMorris, Andrew P.en_US
dc.contributor.authorMüller, Gabrieleen_US
dc.contributor.authorMusk, Arthur W.en_US
dc.contributor.authorNarisu, Narisuen_US
dc.contributor.authorOng, Ken K.en_US
dc.contributor.authorOostra, Ben A.en_US
dc.contributor.authorOsmond, Cliveen_US
dc.contributor.authorPalotie, Aarnoen_US
dc.contributor.authorPankow, James S.en_US
dc.contributor.authorPaternoster, Laviniaen_US
dc.contributor.authorPenninx, Brenda W.en_US
dc.contributor.authorPichler, Ireneen_US
dc.contributor.authorPilia, Maria G.en_US
dc.contributor.authorPolašek, Ozrenen_US
dc.contributor.authorPramstaller, Peter P.en_US
dc.contributor.authorRaitakari, Olli Ten_US
dc.contributor.authorRankinen, Tuomoen_US
dc.contributor.authorRao, D. C.en_US
dc.contributor.authorRayner, Nigel W.en_US
dc.contributor.authorRibel-Madsen, Rasmusen_US
dc.contributor.authorRice, Treva K.en_US
dc.contributor.authorRichards, Marcusen_US
dc.contributor.authorRidker, Paul M.en_US
dc.contributor.authorRivadeneira, Fernandoen_US
dc.contributor.authorRyan, Kathy A.en_US
dc.contributor.authorSanna, Serenaen_US
dc.contributor.authorSarzynski, Mark A.en_US
dc.contributor.authorScholtens, Salomeen_US
dc.contributor.authorScott, Robert A.en_US
dc.contributor.authorSebert, Sylvainen_US
dc.contributor.authorSoutham, Lorraineen_US
dc.contributor.authorSparsø, Thomas Hempelen_US
dc.contributor.authorSteinthorsdottir, Valgerduren_US
dc.contributor.authorStirrups, Kathleenen_US
dc.contributor.authorStolk, Ronald P.en_US
dc.contributor.authorStrauch, Konstantinen_US
dc.contributor.authorStringham, Heather M.en_US
dc.contributor.authorSwertz, Morris A.en_US
dc.contributor.authorSwift, Amy J.en_US
dc.contributor.authorTönjes, Ankeen_US
dc.contributor.authorTsafantakis, Emmanouilen_US
dc.contributor.authorvan der Most, Peter J.en_US
dc.contributor.authorVan Vliet-Ostaptchouk, Jana V.en_US
dc.contributor.authorVandenput, Liesbethen_US
dc.contributor.authorVartiainen, Erkkien_US
dc.contributor.authorVenturini, Cristinaen_US
dc.contributor.authorVerweij, Nieken_US
dc.contributor.authorViikari, Jorma S.en_US
dc.contributor.authorVitart, Veroniqueen_US
dc.contributor.authorVohl, Marie-Claudeen_US
dc.contributor.authorVonk, Judith M.en_US
dc.contributor.authorWaeber, Gérarden_US
dc.contributor.authorWidén, Elisabethen_US
dc.contributor.authorWillemsen, Gonnekeen_US
dc.contributor.authorWilsgaard, Tomen_US
dc.contributor.authorWinkler, Thomas W.en_US
dc.contributor.authorWright, Alan F.en_US
dc.contributor.authorYerges-Armstrong, Laura M.en_US
dc.contributor.authorHua Zhao, Jingen_US
dc.contributor.authorCarola Zillikens, M.en_US
dc.contributor.authorBoomsma, Dorret I.en_US
dc.contributor.authorBouchard, Claudeen_US
dc.contributor.authorChambers, John C.en_US
dc.contributor.authorChasman, Daniel I.en_US
dc.contributor.authorCusi, Danieleen_US
dc.contributor.authorGansevoort, Ron T.en_US
dc.contributor.authorGieger, Christianen_US
dc.contributor.authorHansen, Torbenen_US
dc.contributor.authorHicks, Andrew A.en_US
dc.contributor.authorHu, Franken_US
dc.contributor.authorHveem, Kristianen_US
dc.contributor.authorJarvelin, Marjo-Riittaen_US
dc.contributor.authorKajantie, Eeroen_US
dc.contributor.authorKooner, Jaspal S.en_US
dc.contributor.authorKuh, Dianaen_US
dc.contributor.authorKuusisto, Johannaen_US
dc.contributor.authorLaakso, Markkuen_US
dc.contributor.authorLakka, Timo A.en_US
dc.contributor.authorLehtimäki, Terhoen_US
dc.contributor.authorMetspalu, Andresen_US
dc.contributor.authorNjølstad, Ingeren_US
dc.contributor.authorOhlsson, Claesen_US
dc.contributor.authorOldehinkel, Albertine J.en_US
dc.contributor.authorPalmer, Lyle J.en_US
dc.contributor.authorPedersen, Olufen_US
dc.contributor.authorPerola, Markusen_US
dc.contributor.authorPeters, Annetteen_US
dc.contributor.authorPsaty, Bruce M.en_US
dc.contributor.authorPuolijoki, Hannuen_US
dc.contributor.authorRauramaa, Raineren_US
dc.contributor.authorRudan, Igoren_US
dc.contributor.authorSalomaa, Veikkoen_US
dc.contributor.authorSchwarz, Peter E. H.en_US
dc.contributor.authorShudiner, Alan R.en_US
dc.contributor.authorSmit, Jan H.en_US
dc.contributor.authorSørensen, Thorkild I. A.en_US
dc.contributor.authorSpector, Timothy D.en_US
dc.contributor.authorStefansson, Karien_US
dc.contributor.authorStumvoll, Michaelen_US
dc.contributor.authorTremblay, Angeloen_US
dc.contributor.authorTuomilehto, Jaakkoen_US
dc.contributor.authorUitterlinden, André G.en_US
dc.contributor.authorUusitupa, Mattien_US
dc.contributor.authorVölker, Uween_US
dc.contributor.authorVollenweider, Peteren_US
dc.contributor.authorWareham, Nicholas J.en_US
dc.contributor.authorWatkins, Hughen_US
dc.contributor.authorWilson, James F.en_US
dc.contributor.authorZeggini, Eleftheriaen_US
dc.contributor.authorAbecasis, Goncalo R.en_US
dc.contributor.authorBoehnke, Michaelen_US
dc.contributor.authorBorecki, Ingrid B.en_US
dc.contributor.authorDeloukas, Panosen_US
dc.contributor.authorvan Duijn, Cornelia M.en_US
dc.contributor.authorFox, Carolineen_US
dc.contributor.authorGroop, Leif C.en_US
dc.contributor.authorHeid, Iris M.en_US
dc.contributor.authorHunter, David J.en_US
dc.contributor.authorKaplan, Robert C.en_US
dc.contributor.authorMcCarthy, Mark I.en_US
dc.contributor.authorNorth, Kari E.en_US
dc.contributor.authorO'Connell, Jeffrey R.en_US
dc.contributor.authorSchlessinger, Daviden_US
dc.contributor.authorThorsteinsdottir, Unnuren_US
dc.contributor.authorStrachan, David P.en_US
dc.contributor.authorFrayling, Timothyen_US
dc.contributor.authorHirschhorn, Joel N.en_US
dc.contributor.authorMüller-Nurasyid, Martinaen_US
dc.contributor.authorLoos, Ruth J. F.en_US
dc.date.accessioned2016-12-02T15:26:22Z
dc.date.issued2016en_US
dc.identifier.citationRied, J. S., J. Jeff M., A. Y. Chu, J. L. Bragg-Gresham, J. van Dongen, J. E. Huffman, T. S. Ahluwalia, et al. 2016. “A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape.” Nature Communications 7 (1): 13357. doi:10.1038/ncomms13357. http://dx.doi.org/10.1038/ncomms13357.en
dc.identifier.issn2041-1723en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:29626223
dc.description.abstractLarge consortia have revealed hundreds of genetic loci associated with anthropometric traits, one trait at a time. We examined whether genetic variants affect body shape as a composite phenotype that is represented by a combination of anthropometric traits. We developed an approach that calculates averaged PCs (AvPCs) representing body shape derived from six anthropometric traits (body mass index, height, weight, waist and hip circumference, waist-to-hip ratio). The first four AvPCs explain >99% of the variability, are heritable, and associate with cardiometabolic outcomes. We performed genome-wide association analyses for each body shape composite phenotype across 65 studies and meta-analysed summary statistics. We identify six novel loci: LEMD2 and CD47 for AvPC1, RPS6KA5/C14orf159 and GANAB for AvPC3, and ARL15 and ANP32 for AvPC4. Our findings highlight the value of using multiple traits to define complex phenotypes for discovery, which are not captured by single-trait analyses, and may shed light onto new pathways.en
dc.language.isoen_USen
dc.publisherNature Publishing Groupen
dc.relation.isversionofdoi:10.1038/ncomms13357en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC5114527/pdf/en
dash.licenseLAAen_US
dc.titleA principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shapeen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalNature Communicationsen
dash.depositing.authorEsko, Tõnuen_US
dc.date.available2016-12-02T15:26:22Z
dc.identifier.doi10.1038/ncomms13357*
dash.authorsorderedfalse
dash.contributor.affiliatedEsko, Tõnu
dash.contributor.affiliatedQi, Lu
dash.contributor.affiliatedPalotie, Aarno
dash.contributor.affiliatedRidker, Paul
dash.contributor.affiliatedHu, Frank
dash.contributor.affiliatedChasman, Daniel
dash.contributor.affiliatedFox, Caroline
dash.contributor.affiliatedHirschhorn, Joel
dash.contributor.affiliatedHunter, David
dc.identifier.orcid0000-0003-1982-6569
dc.identifier.orcid0000-0003-1249-4522


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