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dc.contributor.authorAndrianou, Xanthi D.en_US
dc.contributor.authorGängler, Stephanieen_US
dc.contributor.authorPiciu, Andraen_US
dc.contributor.authorCharisiadis, Pantelisen_US
dc.contributor.authorZira, Christinaen_US
dc.contributor.authorAristidou, Kyriacosen_US
dc.contributor.authorPiciu, Doinaen_US
dc.contributor.authorHauser, Russen_US
dc.contributor.authorMakris, Konstantinos C.en_US
dc.date.accessioned2016-12-02T15:26:27Z
dc.date.issued2016en_US
dc.identifier.citationAndrianou, Xanthi D., Stephanie Gängler, Andra Piciu, Pantelis Charisiadis, Christina Zira, Kyriacos Aristidou, Doina Piciu, Russ Hauser, and Konstantinos C. Makris. 2016. “Human Exposures to Bisphenol A, Bisphenol F and Chlorinated Bisphenol A Derivatives and Thyroid Function.” PLoS ONE 11 (10): e0155237. doi:10.1371/journal.pone.0155237. http://dx.doi.org/10.1371/journal.pone.0155237.en
dc.identifier.issn1932-6203en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:29626229
dc.description.abstractAlthough the increasing prevalence of thyroid nodular disease (TND) has been partially attributed to the more frequent usage of improved diagnostics, environmental factors, such as exposures to thyroid-disrupting chemicals may contribute to TND and altered thyroid function. We investigated the association between exposures to bisphenol A (BPA), its chlorinated derivatives (ClxBPA), and bisphenol F (BPF) with TND and thyroid measures in adult women. A case-control study in Cyprus and Romania (n = 212) was conducted, where cases were those with thyroid nodules (diameter >3mm), and controls without nodules. Serum TSH and free thyroxine and urinary levels of BPA, BPF and ClxBPA were measured using immunoassays and tandem mass spectrometry, respectively. The association between exposures to BPA compounds and TND, adjusting for age, BMI, thyroid hormones and urinary iodine was assessed using logistic regression. Linear regression was used to explore associations between urinary BPA, BPF and ClxBPA and serum thyroid hormones. With the exception of a chlorinated BPA compound (30%), the rest of bisphenols were quantified in 100% of urine samples. A positive and significant (p<0.05) association was observed between urinary BPA and serum TSH that remained after adjusting for urinary creatinine, age, BMI, study site and disease status; there was no significant association between BPF or ClxBPA with TSH. None of the BPA compounds were associated with higher odds of TND. Our study found associations of urinary BPA with TSH but not with BPF or ClxBPA. A larger study would be justified.en
dc.language.isoen_USen
dc.publisherPublic Library of Scienceen
dc.relation.isversionofdoi:10.1371/journal.pone.0155237en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC5082639/pdf/en
dash.licenseLAAen_US
dc.subjectBiology and Life Sciencesen
dc.subjectAnatomyen
dc.subjectEndocrine Systemen
dc.subjectThyroiden
dc.subjectMedicine and Health Sciencesen
dc.subjectBiochemistryen
dc.subjectHormonesen
dc.subjectPeptide Hormonesen
dc.subjectThyroid-Stimulating Hormoneen
dc.subjectThyroid Hormonesen
dc.subjectBiomarkersen
dc.subjectCreatinineen
dc.subjectPeople and Placesen
dc.subjectGeographical Locationsen
dc.subjectAsiaen
dc.subjectCyprusen
dc.subjectEuropeen
dc.subjectPhysical Sciencesen
dc.subjectChemistryen
dc.subjectChemical Elementsen
dc.subjectIodineen
dc.subjectBody Fluidsen
dc.subjectUrineen
dc.subjectPhysiologyen
dc.subjectRomaniaen
dc.titleHuman Exposures to Bisphenol A, Bisphenol F and Chlorinated Bisphenol A Derivatives and Thyroid Functionen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalPLoS ONEen
dash.depositing.authorHauser, Russen_US
dc.date.available2016-12-02T15:26:27Z
dc.identifier.doi10.1371/journal.pone.0155237*
dash.authorsorderedfalse
dash.contributor.affiliatedHauser, Russ


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