Phylogenetic and epidemiologic evidence of multiyear incubation in human rabies

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Phylogenetic and epidemiologic evidence of multiyear incubation in human rabies

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Title: Phylogenetic and epidemiologic evidence of multiyear incubation in human rabies
Author: Boland, Torrey A.; McGuone, Declan; Jindal, Jenelle; Rocha, Marcelo; Cumming, Melissa; Rupprecht, Charles E.; Barbosa, Taciana Fernandes Souza; de Novaes Oliveira, Rafael; Chu, Catherine Jean; Cole, Andrew James; Kotait, Ivanete; Kuzmina, Natalia A.; Yager, Pamela A.; Kuzmin, Ivan V.; Hedley-Whyte, E. Tessa; Brown, Catherine M.; Rosenthal, Eric Scott

Note: Order does not necessarily reflect citation order of authors.

Citation: Boland, Torrey A., Declan McGuone, Jenelle Jindal, Marcelo Rocha, Melissa Cumming, Charles E. Rupprecht, Taciana Fernandes Souza Barbosa, et al. 2014. “Phylogenetic and Epidemiologic Evidence of Multiyear Incubation in Human Rabies.” Annals of Neurology 75 (1) (January): 155–160. doi:10.1002/ana.24016.
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Abstract: Eight years after emigrating from Brazil, an otherwise healthy man developed rabies. An exposure prior to immigration was reported. Genetic analysis revealed a canine rabies virus variant found only in the patient’s home country, and the patient had not traveled internationally since immigrating to the United States. We describe how epidemiological, phylogenetic, and viral sequencing data provided confirmation that rabies encephalomyelitis may present after a long, multiyear incubation period, a consideration that previously has been hypothesized without the ability to exclude a more recent exposure. Accordingly, rabies should be considered in the diagnosis of any acute encephalitis, myelitis, or encephalomyelitis.
Published Version: doi:10.1002/ana.24016
Other Sources: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4118733/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:29663469
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