Homeobox protein VentX induces p53-independent apoptosis in cancer cells

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Homeobox protein VentX induces p53-independent apoptosis in cancer cells

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Title: Homeobox protein VentX induces p53-independent apoptosis in cancer cells
Author: Gao, Hong; Wu, Bin; Le, Yi; Zhu, Zhenglun

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Citation: Gao, Hong, Bin Wu, Yi Le, and Zhenglun Zhu. 2016. “Homeobox protein VentX induces p53-independent apoptosis in cancer cells.” Oncotarget 7 (26): 39719-39729. doi:10.18632/oncotarget.9238. http://dx.doi.org/10.18632/oncotarget.9238.
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Abstract: Identifying novel tumor suppressors holds promise for improving cancer treatment. Our recent studies identified VentX, a homeobox transcriptional factor, as a putative tumor suppressor. Here we demonstrate that VentX exerts strong inhibitory effects on the proliferation and survival of cancer cells, but not primary transformed cells, such as 293T cells. Mechanistically, both in vitro and in vivo data showed that VentX induces apoptosis of cancer cells in a p53-independent manner. We found that VentX expression can be induced by chemotherapeutic agents. Taken together, our findings suggest that VentX may function as a novel therapeutic target in cancer treatment.
Published Version: doi:10.18632/oncotarget.9238
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5129965/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:29738974
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