MicroRNA mir-34 provides robustness to environmental stress response via the DAF-16 network in C. elegans

DSpace/Manakin Repository

MicroRNA mir-34 provides robustness to environmental stress response via the DAF-16 network in C. elegans

Citable link to this page

 

 
Title: MicroRNA mir-34 provides robustness to environmental stress response via the DAF-16 network in C. elegans
Author: Isik, Meltem; Blackwell, T. Keith; Berezikov, Eugene

Note: Order does not necessarily reflect citation order of authors.

Citation: Isik, Meltem, T. Keith Blackwell, and Eugene Berezikov. 2016. “MicroRNA mir-34 provides robustness to environmental stress response via the DAF-16 network in C. elegans.” Scientific Reports 6 (1): 36766. doi:10.1038/srep36766. http://dx.doi.org/10.1038/srep36766.
Full Text & Related Files:
Abstract: Diverse stresses and aging alter expression levels of microRNAs, suggesting a role for these posttranscriptional regulators of gene expression in stress modulation and longevity. Earlier studies demonstrated a central role for the miR-34 family in promoting cell cycle arrest and cell death following stress in human cells. However, the biological significance of this response was unclear. Here we show that in C. elegans mir-34 upregulation is necessary for developmental arrest, correct morphogenesis, and adaptation to a lower metabolic state to protect animals against stress-related damage. Either deletion or overexpression of mir-34 lead to an impaired stress response, which can largely be explained by perturbations in DAF-16/FOXO target gene expression. We demonstrate that mir-34 expression is regulated by the insulin signaling pathway via a negative feedback loop between miR-34 and DAF-16/FOXO. We propose that mir-34 provides robustness to stress response programs by controlling noise in the DAF-16/FOXO-regulated gene network.
Published Version: doi:10.1038/srep36766
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5131338/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:29739096
Downloads of this work:

Show full Dublin Core record

This item appears in the following Collection(s)

 
 

Search DASH


Advanced Search
 
 

Submitters