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dc.contributor.authorChilds, Lauren M.en_US
dc.contributor.authorCai, Francisco Y.en_US
dc.contributor.authorKakani, Evdoxia G.en_US
dc.contributor.authorMitchell, Sara N.en_US
dc.contributor.authorPaton, Dougen_US
dc.contributor.authorGabrieli, Paoloen_US
dc.contributor.authorBuckee, Caroline O.en_US
dc.contributor.authorCatteruccia, Flaminiaen_US
dc.date.accessioned2017-01-03T23:50:05Z
dc.date.issued2016en_US
dc.identifier.citationChilds, Lauren M., Francisco Y. Cai, Evdoxia G. Kakani, Sara N. Mitchell, Doug Paton, Paolo Gabrieli, Caroline O. Buckee, and Flaminia Catteruccia. 2016. “Disrupting Mosquito Reproduction and Parasite Development for Malaria Control.” PLoS Pathogens 12 (12): e1006060. doi:10.1371/journal.ppat.1006060. http://dx.doi.org/10.1371/journal.ppat.1006060.en
dc.identifier.issn1553-7366en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:29739135
dc.description.abstractThe control of mosquito populations with insecticide treated bed nets and indoor residual sprays remains the cornerstone of malaria reduction and elimination programs. In light of widespread insecticide resistance in mosquitoes, however, alternative strategies for reducing transmission by the mosquito vector are urgently needed, including the identification of safe compounds that affect vectorial capacity via mechanisms that differ from fast-acting insecticides. Here, we show that compounds targeting steroid hormone signaling disrupt multiple biological processes that are key to the ability of mosquitoes to transmit malaria. When an agonist of the steroid hormone 20-hydroxyecdysone (20E) is applied to Anopheles gambiae females, which are the dominant malaria mosquito vector in Sub Saharan Africa, it substantially shortens lifespan, prevents insemination and egg production, and significantly blocks Plasmodium falciparum development, three components that are crucial to malaria transmission. Modeling the impact of these effects on Anopheles population dynamics and Plasmodium transmission predicts that disrupting steroid hormone signaling using 20E agonists would affect malaria transmission to a similar extent as insecticides. Manipulating 20E pathways therefore provides a powerful new approach to tackle malaria transmission by the mosquito vector, particularly in areas affected by the spread of insecticide resistance.en
dc.language.isoen_USen
dc.publisherPublic Library of Scienceen
dc.relation.isversionofdoi:10.1371/journal.ppat.1006060en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC5158081/pdf/en
dash.licenseLAAen_US
dc.subjectMedicine and Health Sciencesen
dc.subjectEpidemiologyen
dc.subjectDisease Vectorsen
dc.subjectInsect Vectorsen
dc.subjectMosquitoesen
dc.subjectBiology and Life Sciencesen
dc.subjectOrganismsen
dc.subjectAnimalsen
dc.subjectInvertebratesen
dc.subjectArthropodaen
dc.subjectInsectsen
dc.subjectParasitic Diseasesen
dc.subjectMalariaen
dc.subjectTropical Diseasesen
dc.subjectAgricultureen
dc.subjectAgrochemicalsen
dc.subjectInsecticidesen
dc.subjectPeople and Placesen
dc.subjectDemographyen
dc.subjectDeath Ratesen
dc.subjectPopulation Biologyen
dc.subjectPopulation Metricsen
dc.subjectProtozoansen
dc.subjectParasitic Protozoansen
dc.subjectMalarial Parasitesen
dc.subjectAnatomyen
dc.subjectBody Fluidsen
dc.subjectBlooden
dc.subjectPhysiologyen
dc.subjectHematologyen
dc.subjectParasitologyen
dc.subjectParasite Groupsen
dc.subjectApicomplexaen
dc.subjectPlasmodiumen
dc.subjectBiochemistryen
dc.subjectHormonesen
dc.subjectSteroid Hormonesen
dc.titleDisrupting Mosquito Reproduction and Parasite Development for Malaria Controlen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalPLoS Pathogensen
dash.depositing.authorCai, Francisco Y.en_US
dc.date.available2017-01-03T23:50:05Z
dc.identifier.doi10.1371/journal.ppat.1006060*
dash.contributor.affiliatedCai, Francisco Y.
dash.contributor.affiliatedKakani, Evdoxia
dash.contributor.affiliatedCatteruccia, Flaminia


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