dc.contributor.author | Oh, Juhyun | en_US |
dc.contributor.author | Sinha, Indranil | en_US |
dc.contributor.author | Tan, Kah Yong | en_US |
dc.contributor.author | Rosner, Bernard | en_US |
dc.contributor.author | Dreyfuss, Jonathan M. | en_US |
dc.contributor.author | Gjata, Ornela | en_US |
dc.contributor.author | Tran, Peter | en_US |
dc.contributor.author | Shoelson, Steven E. | en_US |
dc.contributor.author | Wagers, Amy J. | en_US |
dc.date.accessioned | 2017-01-03T23:50:17Z | |
dc.date.issued | 2016 | en_US |
dc.identifier.citation | Oh, Juhyun, Indranil Sinha, Kah Yong Tan, Bernard Rosner, Jonathan M. Dreyfuss, Ornela Gjata, Peter Tran, Steven E. Shoelson, and Amy J. Wagers. 2016. “Age-associated NF-κB signaling in myofibers alters the satellite cell niche and re-strains muscle stem cell function.” Aging (Albany NY) 8 (11): 2871-2884. doi:10.18632/aging.101098. http://dx.doi.org/10.18632/aging.101098. | en |
dc.identifier.issn | 1945-4589 | en |
dc.identifier.uri | http://nrs.harvard.edu/urn-3:HUL.InstRepos:29739147 | |
dc.description.abstract | Skeletal muscle is a highly regenerative tissue, but muscle repair potential is increasingly compromised with advancing age. In this study, we demonstrate that increased NF-κB activity in aged muscle fibers contributes to diminished myogenic potential of their associated satellite cells. We further examine the impact of genetic modulation of NF-κB signaling in muscle satellite cells or myofibers on recovery after damage. These studies reveal that NF-κB activity in differentiated myofibers is sufficient to drive dysfunction of muscle regenerative cells via cell-non-autonomous mechanisms. Inhibition of NF-κB, or its downstream target Phospholipase A2, in myofibers rescued muscle regenerative potential in aged muscle. Moreover, systemic administration of sodium salicylate, an FDA-approved NF-κB inhibitor, decreased inflammatory gene expression and improved repair in aged muscle. Together, these studies identify a unique NF-κB regulated, non-cell autonomous mechanism by which stem cell function is linked to lipid signaling and homeostasis, and provide important new targets to stimulate muscle repair in aged individuals. | en |
dc.language.iso | en_US | en |
dc.publisher | Impact Journals LLC | en |
dc.relation.isversionof | doi:10.18632/aging.101098 | en |
dc.relation.hasversion | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5191876/pdf/ | en |
dash.license | LAA | en_US |
dc.subject | satellite cell | en |
dc.subject | skeletal muscle | en |
dc.subject | aging | en |
dc.subject | regeneration | en |
dc.title | Age-associated NF-κB signaling in myofibers alters the satellite cell niche and re-strains muscle stem cell function | en |
dc.type | Journal Article | en_US |
dc.description.version | Version of Record | en |
dc.relation.journal | Aging (Albany NY) | en |
dash.depositing.author | Oh, Juhyun | en_US |
dc.date.available | 2017-01-03T23:50:17Z | |
dc.identifier.doi | 10.18632/aging.101098 | * |
dash.contributor.affiliated | Shoelson, Steven | |
dash.contributor.affiliated | Oh, Juhyun | |
dash.contributor.affiliated | Wagers, Amy | |
dash.contributor.affiliated | Rosner, Bernard | |