dc.contributor.author | Gibson, William J. | en_US |
dc.contributor.author | Hoivik, Erling A. | en_US |
dc.contributor.author | Halle, Mari K. | en_US |
dc.contributor.author | Taylor-Weiner, Amaro | en_US |
dc.contributor.author | Cherniack, Andrew D. | en_US |
dc.contributor.author | Berg, Anna | en_US |
dc.contributor.author | Holst, Frederik | en_US |
dc.contributor.author | Zack, Travis I. | en_US |
dc.contributor.author | Werner, Henrica M. J. | en_US |
dc.contributor.author | Staby, Kjersti M. | en_US |
dc.contributor.author | Rosenberg, Mara | en_US |
dc.contributor.author | Stefansson, Ingunn M. | en_US |
dc.contributor.author | Kusonmano, Kanthida | en_US |
dc.contributor.author | Chevalier, Aaron | en_US |
dc.contributor.author | Mauland, Karen K. | en_US |
dc.contributor.author | Trovik, Jone | en_US |
dc.contributor.author | Krakstad, Camilla | en_US |
dc.contributor.author | Giannakis, Marios | en_US |
dc.contributor.author | Hodis, Eran | en_US |
dc.contributor.author | Woie, Kathrine | en_US |
dc.contributor.author | Bjorge, Line | en_US |
dc.contributor.author | Vintermyr, Olav K. | en_US |
dc.contributor.author | Wala, Jeremiah A. | en_US |
dc.contributor.author | Lawrence, Michael S. | en_US |
dc.contributor.author | Getz, Gad | en_US |
dc.contributor.author | Carter, Scott L. | en_US |
dc.contributor.author | Beroukhim, Rameen | en_US |
dc.contributor.author | Salvesen, Helga B. | en_US |
dc.date.accessioned | 2017-01-03T23:50:20Z | |
dc.date.issued | 2016 | en_US |
dc.identifier.citation | Gibson, W. J., E. A. Hoivik, M. K. Halle, A. Taylor-Weiner, A. D. Cherniack, A. Berg, F. Holst, et al. 2016. “The genomic landscape and evolution of endometrial carcinoma progression and abdominopelvic metastasis.” Nature genetics 48 (8): 848-855. doi:10.1038/ng.3602. http://dx.doi.org/10.1038/ng.3602. | en |
dc.identifier.issn | 1061-4036 | en |
dc.identifier.uri | http://nrs.harvard.edu/urn-3:HUL.InstRepos:29739151 | |
dc.description.abstract | Recent studies have detailed the genomic landscape of primary endometrial cancers, but their evolution into metastases has not been characterized. We performed whole-exome sequencing of 98 tumor biopsies including complex atypical hyperplasias, primary tumors, and paired abdominopelvic metastases to survey the evolutionary landscape of endometrial cancer. We expanded and reanalyzed TCGA-data, identifying novel recurrent alterations in primary tumors, including mutations in the estrogen receptor cofactor NRIP1 in 12% of patients. We found that likely driver events tended to be shared by primary and metastatic tissue-samples, with notable exceptions such as ARID1A mutations. Phylogenetic analyses indicated that the sampled metastases typically arose from a common ancestral subclone that was not detected in the primary tumor biopsy. These data demonstrate extensive genetic heterogeneity within endometrial cancers and relative homogeneity across metastatic sites. | en |
dc.language.iso | en_US | en |
dc.relation.isversionof | doi:10.1038/ng.3602 | en |
dc.relation.hasversion | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4963271/pdf/ | en |
dash.license | LAA | en_US |
dc.subject | Cancer | en |
dc.subject | Metastasis | en |
dc.subject | Precursor | en |
dc.subject | Endometrial cancer | en |
dc.subject | Cancer genomics | en |
dc.subject | Cancer evolution | en |
dc.title | The genomic landscape and evolution of endometrial carcinoma progression and abdominopelvic metastasis | en |
dc.type | Journal Article | en_US |
dc.description.version | Version of Record | en |
dc.relation.journal | Nature genetics | en |
dash.depositing.author | Gibson, William J. | en_US |
dc.date.available | 2017-01-03T23:50:20Z | |
dc.identifier.doi | 10.1038/ng.3602 | * |
dash.authorsordered | false | |
dash.contributor.affiliated | Hodis, Eran | |
dash.contributor.affiliated | Giannakis, Marios | |
dash.contributor.affiliated | Zack, Travis Ian | |
dash.contributor.affiliated | Gibson, William | |
dash.contributor.affiliated | Lawrence, Michael | |
dash.contributor.affiliated | Carter, Scott | |
dash.contributor.affiliated | Wala, Jeremiah | |
dash.contributor.affiliated | Beroukhim, Rameen | |