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dc.contributor.authorAibana, Omowunmien_US
dc.contributor.authorAcharya, Xenoen_US
dc.contributor.authorHuang, Chuan-Chinen_US
dc.contributor.authorBecerra, Mercedes C.en_US
dc.contributor.authorGalea, Jerome T.en_US
dc.contributor.authorChiang, Silvia S.en_US
dc.contributor.authorContreras, Carmenen_US
dc.contributor.authorCalderon, Rogeren_US
dc.contributor.authorYataco, Rosaen_US
dc.contributor.authorVelásquez, Gustavo E.en_US
dc.contributor.authorTintaya, Karenen_US
dc.contributor.authorJimenez, Judithen_US
dc.contributor.authorLecca, Leoniden_US
dc.contributor.authorMurray, Megan B.en_US
dc.date.accessioned2017-01-03T23:51:08Z
dc.date.issued2016en_US
dc.identifier.citationAibana, O., X. Acharya, C. Huang, M. C. Becerra, J. T. Galea, S. S. Chiang, C. Contreras, et al. 2016. “Nutritional Status and Tuberculosis Risk in Adult and Pediatric Household Contacts.” PLoS ONE 11 (11): e0166333. doi:10.1371/journal.pone.0166333. http://dx.doi.org/10.1371/journal.pone.0166333.en
dc.identifier.issn1932-6203en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:29739206
dc.description.abstractBackground: Studies show obesity decreases risk of tuberculosis (TB) disease. There is limited evidence on whether high body mass index also protects against TB infection; how very high body mass indices influence TB risk; or whether nutritional status predicts this risk in children. We assessed the impact of body mass index on incident TB infection and disease among adults and children. Methods and Findings: We conducted a prospective cohort study among household contacts of pulmonary TB cases in Lima, Peru. We determined body mass index at baseline and followed participants for one year for TB infection and disease. We used Cox proportional regression analyses to estimate hazard ratios for incident TB infection and disease. We enrolled 14,044 household contacts, and among 6853 negative for TB infection and disease at baseline, 1787 (26.1%) became infected. A total of 406 contacts developed secondary TB disease during follow-up. Body mass index did not predict risk of TB infection but overweight household contacts had significantly decreased risk of TB disease (HR 0.48; 95% CI 0.37–0.64; p <0.001) compared to those with normal weight. Among adults, body mass index ≥ 35 kg/m2 continued to predict a lower risk of TB disease (HR 0.30; 95% CI 0.12–0.74; p 0.009). We found no association between high body mass index and TB infection or disease among children under 12 years of age. Conclusions: High body mass index protects adults against TB disease even at levels ≥ 35 kg/m2. This protective effect does not extend to TB infection and is not seen in children.en
dc.language.isoen_USen
dc.publisherPublic Library of Scienceen
dc.relation.isversionofdoi:10.1371/journal.pone.0166333en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC5105945/pdf/en
dash.licenseLAAen_US
dc.subjectMedicine and Health Sciencesen
dc.subjectInfectious Diseasesen
dc.subjectBacterial Diseasesen
dc.subjectTuberculosisen
dc.subjectTropical Diseasesen
dc.subjectBiology and Life Sciencesen
dc.subjectPhysiologyen
dc.subjectPhysiological Parametersen
dc.subjectBody Weighten
dc.subjectBody Mass Indexen
dc.subjectOrganismsen
dc.subjectBacteriaen
dc.subjectActinobacteriaen
dc.subjectMycobacterium Tuberculosisen
dc.subjectObesityen
dc.subjectNutritionen
dc.subjectDiagnostic Medicineen
dc.subjectTuberculosis Diagnosis and Managementen
dc.subjectMedicine and health sciencesen
dc.subjectPublic and occupational healthen
dc.subjectPreventive medicineen
dc.subjectHIV preventionen
dc.subjectVascular Medicineen
dc.subjectBlood Pressureen
dc.subjectHypertensionen
dc.titleNutritional Status and Tuberculosis Risk in Adult and Pediatric Household Contactsen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalPLoS ONEen
dash.depositing.authorHuang, Chuan-Chinen_US
dc.date.available2017-01-03T23:51:08Z
dc.identifier.doi10.1371/journal.pone.0166333*
dash.authorsorderedfalse
dash.contributor.affiliatedHuang, Chuan-Chin
dash.contributor.affiliatedGalea, Jerome T.
dash.contributor.affiliatedBecerra, Mercedes
dash.contributor.affiliatedMurray, Megan


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