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dc.contributor.authorChen, Irisen_US
dc.contributor.authorChau, Gordonen_US
dc.contributor.authorWang, Jingen_US
dc.contributor.authorClarke, Williamen_US
dc.contributor.authorMarzinke, Mark A.en_US
dc.contributor.authorCummings, Vanessaen_US
dc.contributor.authorBreaud, Autumnen_US
dc.contributor.authorLaeyendecker, Oliveren_US
dc.contributor.authorFields, Sheldon D.en_US
dc.contributor.authorGriffith, Samen_US
dc.contributor.authorScott, Hyman M.en_US
dc.contributor.authorShoptaw, Stevenen_US
dc.contributor.authordel Rio, Carlosen_US
dc.contributor.authorMagnus, Manyaen_US
dc.contributor.authorMannheimer, Sharonen_US
dc.contributor.authorTieu, Hong-Vanen_US
dc.contributor.authorWheeler, Darrell P.en_US
dc.contributor.authorMayer, Kenneth H.en_US
dc.contributor.authorKoblin, Beryl A.en_US
dc.contributor.authorEshleman, Susan H.en_US
dc.date.accessioned2017-01-03T23:51:11Z
dc.date.issued2016en_US
dc.identifier.citationChen, I., G. Chau, J. Wang, W. Clarke, M. A. Marzinke, V. Cummings, A. Breaud, et al. 2016. “Analysis of HIV Diversity in HIV-Infected Black Men Who Have Sex with Men (HPTN 061).” PLoS ONE 11 (12): e0167629. doi:10.1371/journal.pone.0167629. http://dx.doi.org/10.1371/journal.pone.0167629.en
dc.identifier.issn1932-6203en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:29739214
dc.description.abstractBackground: HIV populations often diversify in response to selective pressures, such as the immune response and antiretroviral drug use. We analyzed HIV diversity in Black men who have sex with men who were enrolled in the HIV Prevention Trials Network 061 study. Methods: A high resolution melting (HRM) diversity assay was used to measure diversity in six regions of the HIV genome: two in gag, one in pol, and three in env. HIV diversity was analyzed for 146 men who were HIV infected at study enrollment, including three with acute infection and 13 with recent infection (identified using a multi-assay algorithm), and for 21 men who seroconverted during the study. HIV diversification was analyzed in a paired analysis for 62 HIV-infected men using plasma samples from the enrollment and 12-month (end of study) visits. Results: Men with acute or recent infection at enrollment and seroconverters had lower median HRM scores (lower HIV diversity) than men with non-recent infection in all six regions analyzed. In univariate analyses, younger age, higher CD4 cell count, and HIV drug resistance were associated with lower median HRM scores in multiple regions; ARV drug detection was marginally associated with lower diversity in the pol region. In multivariate analysis, acute or recent infection (all six regions) and HIV drug resistance (both gag regions) were associated with lower median HRM scores. Diversification in the pol region over 12 months was greater for men with acute or recent infection, higher CD4 cell count, and lower HIV viral load at study enrollment. Conclusions: HIV diversity was significantly associated with duration of HIV infection, and lower gag diversity was observed in men who had HIV drug resistance. HIV pol diversification was more pronounced in men with acute or recent infection, higher CD4 cell count, and lower HIV viral load.en
dc.language.isoen_USen
dc.publisherPublic Library of Scienceen
dc.relation.isversionofdoi:10.1371/journal.pone.0167629en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC5147928/pdf/en
dash.licenseLAAen_US
dc.subjectBiology and Life Sciencesen
dc.subjectMicrobiologyen
dc.subjectMedical Microbiologyen
dc.subjectMicrobial Pathogensen
dc.subjectViral Pathogensen
dc.subjectImmunodeficiency Virusesen
dc.subjectHIVen
dc.subjectMedicine and Health Sciencesen
dc.subjectPathology and Laboratory Medicineen
dc.subjectPathogensen
dc.subjectOrganismsen
dc.subjectVirusesen
dc.subjectBiology and life sciencesen
dc.subjectRNA virusesen
dc.subjectRetrovirusesen
dc.subjectLentivirusen
dc.subjectMicrobial Controlen
dc.subjectAntimicrobial Resistanceen
dc.subjectPharmacologyen
dc.subjectMedicine and health sciencesen
dc.subjectInfectious diseasesen
dc.subjectViral diseasesen
dc.subjectHIV infectionsen
dc.subjectVirologyen
dc.subjectViral Transmission and Infectionen
dc.subjectViral Loaden
dc.subjectPhysical Sciencesen
dc.subjectPhysicsen
dc.subjectCondensed Matter Physicsen
dc.subjectPhase Transitionsen
dc.subjectMeltingen
dc.subjectDrug Screeningen
dc.subjectMathematical and Statistical Techniquesen
dc.subjectStatistical Methodsen
dc.subjectMultivariate Analysisen
dc.subjectMathematicsen
dc.subjectStatistics (Mathematics)en
dc.subjectPeople and Placesen
dc.subjectPopulation Groupingsen
dc.subjectSexuality Groupingsen
dc.subjectMen WHO Have Sex with Menen
dc.titleAnalysis of HIV Diversity in HIV-Infected Black Men Who Have Sex with Men (HPTN 061)en
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalPLoS ONEen
dash.depositing.authorMayer, Kenneth H.en_US
dc.date.available2017-01-03T23:51:11Z
dc.identifier.doi10.1371/journal.pone.0167629*
dash.authorsorderedfalse
dash.contributor.affiliatedMayer, Kenneth
dc.identifier.orcid0000-0001-7460-733X


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