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dc.contributor.authorWallbank, Richard W. R.
dc.contributor.authorBaxter, Simon W.
dc.contributor.authorPardo-Diaz, Carolina
dc.contributor.authorHanly, Joseph J.
dc.contributor.authorMartin, Simon H.
dc.contributor.authorMallet, James
dc.contributor.authorDasmahapatra, Kanchon K.
dc.contributor.authorSalazar, Camilo
dc.contributor.authorJoron, Mathieu
dc.contributor.authorNadeau, Nicola
dc.contributor.authorMcMillan, W. Owen
dc.contributor.authorJiggins, Chris D.
dc.date.accessioned2017-02-13T15:37:36Z
dc.date.issued2016
dc.identifier.citationWallbank, Richard W. R., Simon W. Baxter, Carolina Pardo-Diaz, Joseph J. Hanly, Simon H. Martin, James Mallet, Kanchon K. Dasmahapatra, et al. 2016. Evolutionary Novelty in a Butterfly Wing Pattern through Enhancer Shuffling. Edited by Nick H. Barton. PLOS Biology 14, no. 1: e1002353. doi:10.1371/journal.pbio.1002353.en_US
dc.identifier.issn1545-7885en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:30212073
dc.description.abstractAn important goal in evolutionary biology is to understand the genetic changes underlying novel morphological structures. We investigated the origins of a complex wing pattern found among Amazonian Heliconius butterflies. Genome sequence data from 142 individuals across 17 species identified narrow regions associated with two distinct red colour pattern elements, dennis and ray. We hypothesise that these modules in non-coding sequence represent distinct cis-regulatory loci that control expression of the transcription factor optix, which in turn controls red pattern variation across Heliconius. Phylogenetic analysis of the two elements demonstrated that they have distinct evolutionary histories and that novel adaptive morphological variation was created by shuffling these cis-regulatory modules through recombination between divergent lineages. In addition, recombination of modules into different combinations within species further contributes to diversity. Analysis of the timing of diversification in these two regions supports the hypothesis of introgression moving regulatory modules between species, rather than shared ancestral variation. The dennis phenotype introgressed into Heliconius melpomene at about the same time that ray originated in this group, while ray introgressed back into H. elevatus much more recently. We show that shuffling of existing enhancer elements both within and between species provides a mechanism for rapid diversification and generation of novel morphological combinations during adaptive radiation.en_US
dc.description.sponsorshipOrganismic and Evolutionary Biologyen_US
dc.language.isoen_USen_US
dc.publisherPublic Library of Science (PLoS)en_US
dc.relation.isversionofdoi:10.1371/journal.pbio.1002353en_US
dash.licenseLAA
dc.titleEvolutionary Novelty in a Butterfly Wing Pattern through Enhancer Shufflingen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalPLOS Biologyen_US
dash.depositing.authorMallet, James
dc.date.available2017-02-13T15:37:36Z
dc.identifier.doi10.1371/journal.pbio.1002353*
dash.authorsorderedfalse
dash.contributor.affiliatedMallet, James


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