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dc.contributor.authorMartin, S. H.
dc.contributor.authorDasmahapatra, K. K.
dc.contributor.authorNadeau, N. J.
dc.contributor.authorSalazar, C.
dc.contributor.authorWalters, J. R.
dc.contributor.authorSimpson, F.
dc.contributor.authorBlaxter, M.
dc.contributor.authorManica, A.
dc.contributor.authorMallet, James
dc.contributor.authorJiggins, C. D.
dc.date.accessioned2017-02-13T15:39:04Z
dc.date.issued2013
dc.identifier.citationMartin, S. H., K. K. Dasmahapatra, N. J. Nadeau, C. Salazar, J. R. Walters, F. Simpson, M. Blaxter, A. Manica, J. Mallet, and C. D. Jiggins. 2013. Genome-Wide Evidence for Speciation with Gene Flow in Heliconius Butterflies. Genome Research 23, no. 11: 1817–1828. doi:10.1101/gr.159426.113.en_US
dc.identifier.issn1088-9051en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:30212074
dc.description.abstractMost speciation events probably occur gradually, without complete and immediate reproductive isolation, but the full extent of gene flow between diverging species has rarely been characterized on a genome-wide scale. Documenting the extent and timing of admixture between diverging species can clarify the role of geographic isolation in speciation. Here we use new methodology to quantify admixture at different stages of divergence in Heliconius butterflies, based on wholegenome sequences of 31 individuals. Comparisons between sympatric and allopatric populations of H. melpomene, H. cydno, and H. timareta revealed a genome-wide trend of increased shared variation in sympatry, indicative of pervasive interspecific gene flow. Up to 40% of 100-kb genomic windows clustered by geography rather than by species, demonstrating that a very substantial fraction of the genome has been shared between sympatric species. Analyses of genetic variation shared over different time intervals suggested that admixture between these species has continued since early in speciation. Alleles shared between species during recent time intervals displayed higher levels of linkage disequilibrium than those shared over longer time intervals, suggesting that this admixture took place at multiple points during divergence and is probably ongoing. The signal of admixture was significantly reduced around loci controlling divergent wing patterns, as well as throughout the Z chromosome, consistent with strong selection for Mu¨llerian mimicry and with known Z linked hybrid incompatibility. Overall these results show that species divergence can occur in the face of persistent and genome-wide admixture over long periods of time.en_US
dc.description.sponsorshipOrganismic and Evolutionary Biologyen_US
dc.language.isoen_USen_US
dc.publisherCold Spring Harbor Laboratory Pressen_US
dc.relation.isversionofdoi:10.1101/gr.159426.113en_US
dash.licenseLAA
dc.titleGenome-wide evidence for speciation with gene flow in Heliconius butterfliesen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalGenome Researchen_US
dash.depositing.authorMallet, James
dc.date.available2017-02-13T15:39:04Z
dc.identifier.doi10.1101/gr.159426.113*
dash.contributor.affiliatedMallet, James


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