Autocatalytic, bistable, oscillatory networks of biologically relevant organic reactions

DSpace/Manakin Repository

Autocatalytic, bistable, oscillatory networks of biologically relevant organic reactions

Citable link to this page

 

 
Title: Autocatalytic, bistable, oscillatory networks of biologically relevant organic reactions
Author: Semenov, Sergey N.; Kraft, Lewis J.; Ainla, Alar; Zhao, Mengxia; Baghbanzadeh, Mostafa; Campbell, Victoria; Kang, Kyungtae; Fox, Jerome; Whitesides, George McClelland

Note: Order does not necessarily reflect citation order of authors.

Citation: Semenov, Sergey N., Lewis J. Kraft, Alar Ainla, Mengxia Zhao, Mostafa Baghbanzadeh, Victoria E. Campbell, Kyungtae Kang, Jerome M. Fox, and George M. Whitesides. 2016. Autocatalytic, Bistable, Oscillatory Networks of Biologically Relevant Organic Reactions. Nature 537, no. 7622: 656–660. doi:10.1038/nature19776.
Full Text & Related Files:
Abstract: Networks of organic chemical reactions are centrally important in life, and were likely to have played a central role in its origins. Network dynamics regulate cell division, circadian rhythms, nerve impulses, chemotaxis, and guide development of organisms. Although out-of-equilibrium networks of chemical reactions have the potential to display emergent network dynamics such as spontaneous pattern formation, bistability, and periodic oscillations, the principles that enable networks of organic reactions to develop complex behaviors are incompletely understood. Here we describe a network of biologically relevant organic reactions (amide formation, thiolate-thioester exchange, thiolate-disulfide interchange, and conjugate addition) that displays bistability and oscillations in concentrations of organic thiols and amides. Oscillations arise from the interaction between three subcomponents of the network: (i) an autocatalytic cycle that generates thiols and amides from thioesters and dialkyl disulfides; (ii) a trigger that controls autocatalytic growth; and (iii) inhibitory processes that remove activating thiol species produced during the autocatalytic cycle. In contrast to previous studies demonstrating oscillations and bistability using highly evolved biomolecules (i.e., enzymes and DNA) or inorganic molecules of questionable biochemical relevance (e.g. those used in Belousov-Zhabotinsky-type reactions), the organic molecules used in our network are relevant to current metabolism and similar to those that might have existed on early Earth. By using small organic molecules to build a network of organic reactions with autocatalytic, bistable, and oscillatory behavior, we identified principles that clarify how dynamic networks relevant to life might possibly have developed. In the future, modifications of this network will clarify the influence of molecular structure on the dynamics of reaction networks, and may enable the design of biomimetic networks, and of synthetic self-regulating and evolving chemical systems.
Published Version: 10.1038/nature19776
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:30353769
Downloads of this work:

Show full Dublin Core record

This item appears in the following Collection(s)

 
 

Search DASH


Advanced Search
 
 

Submitters