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dc.contributor.authorBirchler-Pedross, Angelinaen_US
dc.contributor.authorFrey, Sylviaen_US
dc.contributor.authorGötz, Thomasen_US
dc.contributor.authorBrunner, Patricken_US
dc.contributor.authorKnoblauch, Veraen_US
dc.contributor.authorWirz-Justice, Annaen_US
dc.contributor.authorChellappa, Sarah L.en_US
dc.contributor.authorCajochen, Christianen_US
dc.date.accessioned2017-02-18T01:58:10Z
dc.date.issued2016en_US
dc.identifier.citationBirchler-Pedross, Angelina, Sylvia Frey, Thomas Götz, Patrick Brunner, Vera Knoblauch, Anna Wirz-Justice, Sarah L. Chellappa, and Christian Cajochen. 2016. “Subjective Mood in Young Unmedicated Depressed Women under High and Low Sleep Pressure Conditions.” Biology 5 (4): 52. doi:10.3390/biology5040052. http://dx.doi.org/10.3390/biology5040052.en
dc.identifier.issn2079-7737en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:30370968
dc.description.abstractDiurnal mood variations are one of the core symptoms in depression, and total sleep deprivation (SD) can induce rapid, short-lasting clinical improvement in depressed patients. Here, we investigated if differential sleep pressure conditions impact on subjective mood levels in young women with major depressive disorder (MDD) without sleep disturbances, and in healthy controls. Eight healthy and eight MDD women underwent 40-h SD (high sleep pressure) and 40-h multiple NAP (low sleep pressure) protocols under constant routine conditions during which subjective mood was assessed every 30-min. MDD women rated overall significantly worse mood than controls, with minimal values for both groups during the biological night (ca. 4 a.m.), under high and low sleep pressure conditions. During SD, nighttime mood ratings in MDD women were lower than in controls and partially recovered during the second day of SD, but never attained control levels. The degree of this diurnal time-course in mood under SD correlated positively with sleep quality in MDD women. Our data indicate that MDD women without sleep disturbances did not exhibit a SD-induced antidepressant response, suggesting that the mood enhancement response to sleep deprivation might be related to the co-existence of sleep disturbances, which is an association that remains to be fully established.en
dc.language.isoen_USen
dc.publisherMDPIen
dc.relation.isversionofdoi:10.3390/biology5040052en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC5192432/pdf/en
dash.licenseLAAen_US
dc.subjectmajor depressive disorderen
dc.subjectsleep deprivationen
dc.subjectmooden
dc.subjectcircadian rhythmsen
dc.subjectsleep homeostasisen
dc.titleSubjective Mood in Young Unmedicated Depressed Women under High and Low Sleep Pressure Conditionsen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalBiologyen
dash.depositing.authorChellappa, Sarah L.en_US
dc.date.available2017-02-18T01:58:10Z
dc.identifier.doi10.3390/biology5040052*
dash.contributor.affiliatedChellappa, Sarah


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