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dc.contributor.authorGao, Jianjiongen_US
dc.contributor.authorChang, Matthew T.en_US
dc.contributor.authorJohnsen, Hannah C.en_US
dc.contributor.authorGao, Sizhi Paulen_US
dc.contributor.authorSylvester, Brooke E.en_US
dc.contributor.authorSumer, Selcuk Onuren_US
dc.contributor.authorZhang, Hongxinen_US
dc.contributor.authorSolit, David B.en_US
dc.contributor.authorTaylor, Barry S.en_US
dc.contributor.authorSchultz, Nikolausen_US
dc.contributor.authorSander, Chrisen_US
dc.date.accessioned2017-02-18T01:58:16Z
dc.date.issued2017en_US
dc.identifier.citationGao, J., M. T. Chang, H. C. Johnsen, S. P. Gao, B. E. Sylvester, S. O. Sumer, H. Zhang, et al. 2017. “3D clusters of somatic mutations in cancer reveal numerous rare mutations as functional targets.” Genome Medicine 9 (1): 4. doi:10.1186/s13073-016-0393-x. http://dx.doi.org/10.1186/s13073-016-0393-x.en
dc.identifier.issn1756-994Xen
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:30370985
dc.description.abstractMany mutations in cancer are of unknown functional significance. Standard methods use statistically significant recurrence of mutations in tumor samples as an indicator of functional impact. We extend such analyses into the long tail of rare mutations by considering recurrence of mutations in clusters of spatially close residues in protein structures. Analyzing 10,000 tumor exomes, we identify more than 3000 rarely mutated residues in proteins as potentially functional and experimentally validate several in RAC1 and MAP2K1. These potential driver mutations (web resources: 3dhotspots.org and cBioPortal.org) can extend the scope of genomically informed clinical trials and of personalized choice of therapy. Electronic supplementary material The online version of this article (doi:10.1186/s13073-016-0393-x) contains supplementary material, which is available to authorized users.en
dc.language.isoen_USen
dc.publisherBioMed Centralen
dc.relation.isversionofdoi:10.1186/s13073-016-0393-xen
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC5260099/pdf/en
dash.licenseLAAen_US
dc.subjectCancer genomicsen
dc.subjectDriver mutationsen
dc.subjectProtein structuresen
dc.subjectPrecision medicineen
dc.title3D clusters of somatic mutations in cancer reveal numerous rare mutations as functional targetsen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalGenome Medicineen
dash.depositing.authorSander, Chrisen_US
dc.date.available2017-02-18T01:58:16Z
dc.identifier.doi10.1186/s13073-016-0393-x*
dash.authorsorderedfalse
dash.contributor.affiliatedSander, Chris


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