Enhanced Rb/E2F and TSC/mTOR Pathways Induce Synergistic Inhibition in PDGF-Induced Proliferation in Vascular Smooth Muscle Cells
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Li, Yue
Li, Xuan
Guo, Wei
Zhang, Hongchao
Wang, Jianchang
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https://doi.org/10.1371/journal.pone.0170036Metadata
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Li, Yue, Xuan Li, Jie Liu, Wei Guo, Hongchao Zhang, and Jianchang Wang. 2017. “Enhanced Rb/E2F and TSC/mTOR Pathways Induce Synergistic Inhibition in PDGF-Induced Proliferation in Vascular Smooth Muscle Cells.” PLoS ONE 12 (1): e0170036. doi:10.1371/journal.pone.0170036. http://dx.doi.org/10.1371/journal.pone.0170036.Abstract
Platelet-derived growth factor (PDGF) plays an essential role in proliferation of vascular smooth muscle cells (VSMCs). The Rb/E2F and TSC/mTOR pathways contribute to the proliferation of VSMCs, but its exact roles in PDGF-induced proliferation are unclear. In this study, we demonstrated the roles of Rb/E2F and TSC/mTOR pathways in PDGF-induced proliferation in VSMCs. We found that PDGF stimulates the activity of E2F and mTOR pathways, and knockdown of either Rb or TSC2 increases PDGF-induced proliferation in VSMCs. More interestingly, we revealed that enhancing both E2F and mTOR activity leads to synergistic inhibition of PDGF-induced proliferation in VSMCs. We further identified that the synergistic inhibition effect is caused by the induced oxidative stress. Summarily, these data suggest the important regulations of Rb/E2F and TSC/mTOR pathways in PDGF-induced proliferation in VSMCs, and also present a promising way to limit deregulated proliferation by PDGF induction in VSMCs.Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5226788/pdf/Terms of Use
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