Longitudinal measurement and hierarchical classification framework for the prediction of Alzheimer’s disease

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Author
Huang, Meiyan
Yang, Wei
Feng, Qianjin
Chen, Wufan
Weiner, Michael W.
Aisen, Paul
Petersen, Ronald
Jack, Clifford R.
Jagust, William
Trojanowki, John Q.
Toga, Arthur W.
Beckett, Laurel
Saykin, Andrew J.
Morris, John
Shaw, Leslie M.
Kaye, Jeffrey
Quinn, Joseph
Silbert, Lisa
Lind, Betty
Carter, Raina
Dolen, Sara
Schneider, Lon S.
Pawluczyk, Sonia
Beccera, Mauricio
Teodoro, Liberty
Spann, Bryan M.
Brewer, James
Vanderswag, Helen
Fleisher, Adam
Heidebrink, Judith L.
Lord, Joanne L.
Mason, Sara S.
Albers, Colleen S.
Knopman, David
Johnson, Kris
Doody, Rachelle S.
Villanueva-Meyer, Javier
Chowdhury, Munir
Rountree, Susan
Dang, Mimi
Stern, Yaakov
Honig, Lawrence S.
Bell, Karen L.
Ances, Beau
Morris, John C.
Carroll, Maria
Creech, Mary L.
Franklin, Erin
Mintun, Mark A.
Schneider, Stacy
Oliver, Angela
Marson, Daniel
Griffith, Randall
Clark, David
Geldmacher, David
Brockington, John
Roberson, Erik
Love, Marissa Natelson
Grossman, Hillel
Mitsis, Effie
Shah, Raj C.
deToledo-Morrell, Leyla
Duara, Ranjan
Varon, Daniel
Greig, Maria T.
Roberts, Peggy
Albert, Marilyn
Onyike, Chiadi
D’Agostino, Daniel
Kielb, Stephanie
Galvin, James E.
Cerbone, Brittany
Michel, Christina A.
Pogorelec, Dana M.
Rusinek, Henry
de Leon, Mony J.
Glodzik, Lidia
De Santi, Susan
Doraiswamy, P. Murali
Petrella, Jeffrey R.
Borges-Neto, Salvador
Wong, Terence Z.
Coleman, Edward
Smith, Charles D.
Jicha, Greg
Hardy, Peter
Sinha, Partha
Oates, Elizabeth
Conrad, Gary
Porsteinsson, Anton P.
Goldstein, Bonnie S.
Martin, Kim
Makino, Kelly M.
Ismail, M. Saleem
Brand, Connie
Mulnard, Ruth A.
Thai, Gaby
Mc-Adams-Ortiz, Catherine
Womack, Kyle
Mathews, Dana
Quiceno, Mary
Levey, Allan I.
Lah, James J.
Cellar, Janet S.
Burns, Jeffrey M.
Swerdlow, Russell H.
Brooks, William M.
Apostolova, Liana
Tingus, Kathleen
Woo, Ellen
Silverman, Daniel H. S.
Lu, Po H.
Bartzokis, George
Graff-Radford, Neill R.
Parfitt, Francine
Kendall, Tracy
Johnson, Heather
Farlow, Martin R.
Hake, Ann Marie
Matthews, Brandy R.
Brosch, Jared R.
Herring, Scott
Hunt, Cynthia
van Dyck, Christopher H.
Carson, Richard E.
MacAvoy, Martha G.
Varma, Pradeep
Chertkow, Howard
Bergman, Howard
Hosein, Chris
Black, Sandra
Stefanovic, Bojana
Caldwell, Curtis
Hsiung, Ging-Yuek Robin
Feldman, Howard
Mudge, Benita
Assaly, Michele
Finger, Elizabeth
Pasternack, Stephen
Rachisky, Irina
Trost, Dick
Kertesz, Andrew
Bernick, Charles
Munic, Donna
Mesulam, Marek Marsel
Lipowski, Kristine
Weintraub, Sandra
Bonakdarpour, Borna
Kerwin, Diana
Wu, Chuang-Kuo
Johnson, Nancy
Sadowsky, Carl
Villena, Teresa
Turner, Raymond Scott
Johnson, Kathleen
Reynolds, Brigid
Yesavage, Jerome
Taylor, Joy L.
Lane, Barton
Rosen, Allyson
Tinklenberg, Jared
Sabbagh, Marwan N.
Belden, Christine M.
Jacobson, Sandra A.
Sirrel, Sherye A.
Kowall, Neil
Killiany, Ronald
Budson, Andrew E.
Norbash, Alexander
Johnson, Patricia Lynn
Obisesan, Thomas O.
Wolday, Saba
Allard, Joanne
Lerner, Alan
Ogrocki, Paula
Tatsuoka, Curtis
Fatica, Parianne
Fletcher, Evan
Maillard, Pauline
Olichney, John
DeCarli, Charles
Carmichael, Owen
Kittur, Smita
Borrie, Michael
Lee, T-Y
Bartha, Rob
Johnson, Sterling
Asthana, Sanjay
Carlsson, Cynthia M.
Potkin, Steven G.
Preda, Adrian
Nguyen, Dana
Tariot, Pierre
Burke, Anna
Trncic, Nadira
Reeder, Stephanie
Bates, Vernice
Capote, Horacio
Rainka, Michelle
Scharre, Douglas W.
Kataki, Maria
Adeli, Anahita
Zimmerman, Earl A.
Celmins, Dzintra
Brown, Alice D.
Pearlson, Godfrey D.
Blank, Karen
Anderson, Karen
Flashman, Laura A.
Seltzer, Marc
Hynes, Mary L.
Santulli, Robert B.
Sink, Kaycee M.
Gordineer, Leslie
Williamson, Jeff D.
Garg, Pradeep
Watkins, Franklin
Ott, Brian R.
Querfurth, Henry
Tremont, Geoffrey
Salloway, Stephen
Malloy, Paul
Correia, Stephen
Rosen, Howard J.
Miller, Bruce L.
Perry, David
Mintzer, Jacobo
Spicer, Kenneth
Bachman, David
Pomara, Nunzio
Hernando, Raymundo
Sarrael, Antero
Relkin, Norman
Chaing, Gloria
Lin, Michael
Ravdin, Lisa
Smith, Amanda
Raj, Balebail Ashok
Fargher, Kristin
Note: Order does not necessarily reflect citation order of authors.
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https://doi.org/10.1038/srep39880Metadata
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Huang, M., W. Yang, Q. Feng, W. Chen, M. W. Weiner, P. Aisen, R. Petersen, et al. 2017. “Longitudinal measurement and hierarchical classification framework for the prediction of Alzheimer’s disease.” Scientific Reports 7 (1): 39880. doi:10.1038/srep39880. http://dx.doi.org/10.1038/srep39880.Abstract
Accurate prediction of Alzheimer’s disease (AD) is important for the early diagnosis and treatment of this condition. Mild cognitive impairment (MCI) is an early stage of AD. Therefore, patients with MCI who are at high risk of fully developing AD should be identified to accurately predict AD. However, the relationship between brain images and AD is difficult to construct because of the complex characteristics of neuroimaging data. To address this problem, we present a longitudinal measurement of MCI brain images and a hierarchical classification method for AD prediction. Longitudinal images obtained from individuals with MCI were investigated to acquire important information on the longitudinal changes, which can be used to classify MCI subjects as either MCI conversion (MCIc) or MCI non-conversion (MCInc) individuals. Moreover, a hierarchical framework was introduced to the classifier to manage high feature dimensionality issues and incorporate spatial information for improving the prediction accuracy. The proposed method was evaluated using 131 patients with MCI (70 MCIc and 61 MCInc) based on MRI scans taken at different time points. Results showed that the proposed method achieved 79.4% accuracy for the classification of MCIc versus MCInc, thereby demonstrating very promising performance for AD prediction.Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5227696/pdf/Terms of Use
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http://nrs.harvard.edu/urn-3:HUL.InstRepos:30370990
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