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dc.contributor.authorChiara, Matteoen_US
dc.contributor.authorManzari, Caterinaen_US
dc.contributor.authorLionetti, Claudiaen_US
dc.contributor.authorMechelli, Rosellaen_US
dc.contributor.authorAnastasiadou, Elenien_US
dc.contributor.authorChiara Buscarinu, Mariaen_US
dc.contributor.authorRistori, Giovannien_US
dc.contributor.authorSalvetti, Marcoen_US
dc.contributor.authorPicardi, Ernestoen_US
dc.contributor.authorD’Erchia, Anna Mariaen_US
dc.contributor.authorPesole, Grazianoen_US
dc.contributor.authorHorner, David S.en_US
dc.date.accessioned2017-02-18T01:58:23Z
dc.date.issued2016en_US
dc.identifier.citationChiara, M., C. Manzari, C. Lionetti, R. Mechelli, E. Anastasiadou, M. Chiara Buscarinu, G. Ristori, et al. 2016. “Geographic Population Structure in Epstein-Barr Virus Revealed by Comparative Genomics.” Genome Biology and Evolution 8 (11): 3284-3291. doi:10.1093/gbe/evw226. http://dx.doi.org/10.1093/gbe/evw226.en
dc.identifier.issn1759-6653en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:30371005
dc.description.abstractEpstein-Barr virus (EBV) latently infects the majority of the human population and is implicated as a causal or contributory factor in numerous diseases. We sequenced 27 complete EBV genomes from a cohort of Multiple Sclerosis (MS) patients and healthy controls from Italy, although no variants showed a statistically significant association with MS. Taking advantage of the availability of ∼130 EBV genomes with known geographical origins, we reveal a striking geographic distribution of EBV sub-populations with distinct allele frequency distributions. We discuss mechanisms that potentially explain these observations, and their implications for understanding the association of EBV with human disease.en
dc.language.isoen_USen
dc.publisherOxford University Pressen
dc.relation.isversionofdoi:10.1093/gbe/evw226en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC5203774/pdf/en
dash.licenseLAAen_US
dc.subjectcomparative genomicsen
dc.subjectgenome sequenceen
dc.subjectpopulation structureen
dc.subjectEpstein-Barr virusen
dc.titleGeographic Population Structure in Epstein-Barr Virus Revealed by Comparative Genomicsen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalGenome Biology and Evolutionen
dash.depositing.authorAnastasiadou, Elenien_US
dc.date.available2017-02-18T01:58:23Z
dc.identifier.doi10.1093/gbe/evw226*
dash.authorsorderedfalse
dash.contributor.affiliatedAnastasiadou, Eleni


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