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dc.contributor.authorTseng, Ping-Hueien_US
dc.contributor.authorLee, Pei-Linen_US
dc.contributor.authorHsu, Wei-Chungen_US
dc.contributor.authorMa, Yanen_US
dc.contributor.authorLee, Yi-Chiaen_US
dc.contributor.authorChiu, Han-Moen_US
dc.contributor.authorHo, Yi-Lwunen_US
dc.contributor.authorChen, Ming-Fongen_US
dc.contributor.authorWu, Ming-Shiangen_US
dc.contributor.authorPeng, Chung-Kangen_US
dc.date.accessioned2017-02-18T01:58:28Z
dc.date.issued2017en_US
dc.identifier.citationTseng, Ping-Huei, Pei-Lin Lee, Wei-Chung Hsu, Yan Ma, Yi-Chia Lee, Han-Mo Chiu, Yi-Lwun Ho, Ming-Fong Chen, Ming-Shiang Wu, and Chung-Kang Peng. 2017. “A Higher Proportion of Metabolic Syndrome in Chinese Subjects with Sleep-Disordered Breathing: A Case-Control Study Based on Electrocardiogram-Derived Sleep Analysis.” PLoS ONE 12 (1): e0169394. doi:10.1371/journal.pone.0169394. http://dx.doi.org/10.1371/journal.pone.0169394.en
dc.identifier.issn1932-6203en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:30371019
dc.description.abstractObjective: The prevalence of metabolic syndrome (MS) has increased rapidly in Taiwan and worldwide. We aim to determine the association between sleep-disordered breathing (SDB) and MS in a Chinese general population. Methods: This case-control study recruited subjects who have undergone a prospective electrocardiogram-based cardiopulmonary coupling (CPC) sleep spectrogram as part of the periodic health check-ups at the National Taiwan University Hospital. Comprehensive anthropometrics, blood biochemistry, prevalence of MS and its individual components were compared with Bonferroni correction between 40 subjects with SDB, defined as the CPC-derived apnea–hypopnea index (CPC-AHI) >5 event/hour and 80 age- and sex-matched controls, defined as CPC-AHI <1 event/hour. MS was diagnosed based on the Adult Treatment Panel III, with a modification of waist circumference for Asians. Results: Subjects with SDB were more obese with larger waist circumferences (95.1±12.9 vs. 87.3±6.9, P < .001) and borderline higher BMI (27.0±4.9 vs. 24.3±2.5, P = .002). Waist circumference was independently associated with the presence of SDB after adjustment for BMI, systolic blood pressure and fasting blood glucose in multiple regression analyses. Subjects with SDB had a higher prevalence of central obesity (72.5% vs. 42.5%, P = .002), hyperglycemia (45.0% vs. 26.3%, P = .04), MS (45.0% vs. 22.5%, P = .01) and number of MS components (2.4 ± 1.6 vs. 1.7 ± 1.4, P = .01) than the control group. Waist circumference was significantly correlated with both CPC-AHI (r = .492, P = .0013) and PSG-AHI (r = .699, P < .0001) in the SDB group. Conclusions: SDB was associated with a higher prevalence of MS and its individual components, notably central obesity, in a Chinese general population. Large-scale screening of high risk population with MS to identify subjects with SDB for appropriate management is warranted.en
dc.language.isoen_USen
dc.publisherPublic Library of Scienceen
dc.relation.isversionofdoi:10.1371/journal.pone.0169394en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC5231382/pdf/en
dash.licenseLAAen_US
dc.subjectBiology and Life Sciencesen
dc.subjectPhysiologyen
dc.subjectPhysiological Processesen
dc.subjectSleepen
dc.subjectMedicine and Health Sciencesen
dc.subjectPhysiological Parametersen
dc.subjectBody Weighten
dc.subjectObesityen
dc.subjectRespirationen
dc.subjectBreathingen
dc.subjectBody Mass Indexen
dc.subjectVascular Medicineen
dc.subjectBlood Pressureen
dc.subjectAnatomyen
dc.subjectBody Fluidsen
dc.subjectBlooden
dc.subjectBlood Sugaren
dc.subjectHematologyen
dc.subjectMetabolic Disordersen
dc.subjectHyperglycemiaen
dc.subjectPhysical Sciencesen
dc.subjectMathematicsen
dc.subjectStatistics (Mathematics)en
dc.subjectStatistical Dataen
dc.titleA Higher Proportion of Metabolic Syndrome in Chinese Subjects with Sleep-Disordered Breathing: A Case-Control Study Based on Electrocardiogram-Derived Sleep Analysisen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalPLoS ONEen
dash.depositing.authorMa, Yanen_US
dc.date.available2017-02-18T01:58:28Z
dc.identifier.doi10.1371/journal.pone.0169394*
dash.authorsorderedfalse
dash.contributor.affiliatedMa, Yan
dash.contributor.affiliatedPeng, Chung-Kang


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