Mitochondrial respiratory gene expression is suppressed in many cancers

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Mitochondrial respiratory gene expression is suppressed in many cancers

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Title: Mitochondrial respiratory gene expression is suppressed in many cancers
Author: Reznik, Ed; Wang, Qingguo; La, Konnor; Schultz, Nikolaus; Sander, Chris

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Citation: Reznik, Ed, Qingguo Wang, Konnor La, Nikolaus Schultz, and Chris Sander. 2017. “Mitochondrial respiratory gene expression is suppressed in many cancers.” eLife 6 (1): e21592. doi:10.7554/eLife.21592. http://dx.doi.org/10.7554/eLife.21592.
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Abstract: The fundamental metabolic decision of a cell, the balance between respiration and fermentation, rests in part on expression of the mitochondrial genome (mtDNA) and coordination with expression of the nuclear genome (nuDNA). Previously we described mtDNA copy number depletion across many solid tumor types (Reznik et al., 2016). Here, we use orthogonal RNA-sequencing data to quantify mtDNA expression (mtRNA), and report analogously lower expression of mtRNA in tumors (relative to normal tissue) across a majority of cancer types. Several cancers exhibit a trio of mutually consistent evidence suggesting a drop in respiratory activity: depletion of mtDNA copy number, decreases in mtRNA levels, and decreases in expression of nuDNA-encoded respiratory proteins. Intriguingly, a minority of cancer types exhibit a drop in mtDNA expression but an increase in nuDNA expression of respiratory proteins, with unknown implications for respiratory activity. Our results indicate suppression of respiratory gene expression across many cancer types. DOI: http://dx.doi.org/10.7554/eLife.21592.001
Published Version: doi:10.7554/eLife.21592
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5243113/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:30371055
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