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dc.contributor.authorReznik, Eden_US
dc.contributor.authorWang, Qingguoen_US
dc.contributor.authorLa, Konnoren_US
dc.contributor.authorSchultz, Nikolausen_US
dc.contributor.authorSander, Chrisen_US
dc.date.accessioned2017-02-18T01:58:40Z
dc.date.issued2017en_US
dc.identifier.citationReznik, Ed, Qingguo Wang, Konnor La, Nikolaus Schultz, and Chris Sander. 2017. “Mitochondrial respiratory gene expression is suppressed in many cancers.” eLife 6 (1): e21592. doi:10.7554/eLife.21592. http://dx.doi.org/10.7554/eLife.21592.en
dc.identifier.issn2050-084Xen
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:30371055
dc.description.abstractThe fundamental metabolic decision of a cell, the balance between respiration and fermentation, rests in part on expression of the mitochondrial genome (mtDNA) and coordination with expression of the nuclear genome (nuDNA). Previously we described mtDNA copy number depletion across many solid tumor types (Reznik et al., 2016). Here, we use orthogonal RNA-sequencing data to quantify mtDNA expression (mtRNA), and report analogously lower expression of mtRNA in tumors (relative to normal tissue) across a majority of cancer types. Several cancers exhibit a trio of mutually consistent evidence suggesting a drop in respiratory activity: depletion of mtDNA copy number, decreases in mtRNA levels, and decreases in expression of nuDNA-encoded respiratory proteins. Intriguingly, a minority of cancer types exhibit a drop in mtDNA expression but an increase in nuDNA expression of respiratory proteins, with unknown implications for respiratory activity. Our results indicate suppression of respiratory gene expression across many cancer types. DOI: http://dx.doi.org/10.7554/eLife.21592.001en
dc.language.isoen_USen
dc.publishereLife Sciences Publications, Ltden
dc.relation.isversionofdoi:10.7554/eLife.21592en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC5243113/pdf/en
dash.licenseLAAen_US
dc.subjectmetabolismen
dc.subjectmitochondriaen
dc.subjectmtDNAen
dc.subjectcanceren
dc.subjectmtRNAen
dc.subjectrespirationen
dc.subjectHumanen
dc.titleMitochondrial respiratory gene expression is suppressed in many cancersen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journaleLifeen
dash.depositing.authorSander, Chrisen_US
dc.date.available2017-02-18T01:58:40Z
dc.identifier.doi10.7554/eLife.21592*
dash.contributor.affiliatedSander, Chris


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