Causal inference as an emerging statistical approach in neurology: an example for epilepsy in the elderly

DSpace/Manakin Repository

Causal inference as an emerging statistical approach in neurology: an example for epilepsy in the elderly

Citable link to this page

 

 
Title: Causal inference as an emerging statistical approach in neurology: an example for epilepsy in the elderly
Author: Moura, Lidia MVR; Westover, M Brandon; Kwasnik, David; Cole, Andrew J; Hsu, John

Note: Order does not necessarily reflect citation order of authors.

Citation: Moura, Lidia MVR, M Brandon Westover, David Kwasnik, Andrew J Cole, and John Hsu. 2017. “Causal inference as an emerging statistical approach in neurology: an example for epilepsy in the elderly.” Clinical Epidemiology 9 (1): 9-18. doi:10.2147/CLEP.S121023. http://dx.doi.org/10.2147/CLEP.S121023.
Full Text & Related Files:
Abstract: The elderly population faces an increasing number of cases of chronic neurological conditions, such as epilepsy and Alzheimer’s disease. Because the elderly with epilepsy are commonly excluded from randomized controlled clinical trials, there are few rigorous studies to guide clinical practice. When the elderly are eligible for trials, they either rarely participate or frequently have poor adherence to therapy, thus limiting both generalizability and validity. In contrast, large observational data sets are increasingly available, but are susceptible to bias when using common analytic approaches. Recent developments in causal inference-analytic approaches also introduce the possibility of emulating randomized controlled trials to yield valid estimates. We provide a practical example of the application of the principles of causal inference to a large observational data set of patients with epilepsy. This review also provides a framework for comparative-effectiveness research in chronic neurological conditions.
Published Version: doi:10.2147/CLEP.S121023
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5221551/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:30371058
Downloads of this work:

Show full Dublin Core record

This item appears in the following Collection(s)

 
 

Search DASH


Advanced Search
 
 

Submitters