Molecular architecture of the complete COG tethering complex
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CitationHa, Jun Yong, Hui-Ting Chou, Daniel Ungar, Calvin K. Yip, Thomas Walz, and Frederick M. Hughson. 2016. “Molecular architecture of the complete COG tethering complex.” Nature structural & molecular biology 23 (8): 758-760. doi:10.1038/nsmb.3263. http://dx.doi.org/10.1038/nsmb.3263.
AbstractThe conserved oligomeric Golgi (COG) complex orchestrates vesicular trafficking to and within the Golgi apparatus. Here, we use negative-stain electron microscopy to elucidate the architecture of the hetero-octameric COG complex from Saccharomyces cerevisiae. Intact COG has an intricate shape, with four (or possibly five) flexible legs, that differs strikingly from the exocyst complex and appears well-suited for vesicle capture and fusion.
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