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dc.contributor.authorHuynh, Elizabethen_US
dc.contributor.authorCoroller, Thibaud P.en_US
dc.contributor.authorNarayan, Viveken_US
dc.contributor.authorAgrawal, Visheshen_US
dc.contributor.authorRomano, Johnen_US
dc.contributor.authorFranco, Idaliden_US
dc.contributor.authorParmar, Chintanen_US
dc.contributor.authorHou, Yingen_US
dc.contributor.authorMak, Raymond H.en_US
dc.contributor.authorAerts, Hugo J. W. L.en_US
dc.date.accessioned2017-02-18T01:59:02Z
dc.date.issued2017en_US
dc.identifier.citationHuynh, Elizabeth, Thibaud P. Coroller, Vivek Narayan, Vishesh Agrawal, John Romano, Idalid Franco, Chintan Parmar, Ying Hou, Raymond H. Mak, and Hugo J. W. L. Aerts. 2017. “Associations of Radiomic Data Extracted from Static and Respiratory-Gated CT Scans with Disease Recurrence in Lung Cancer Patients Treated with SBRT.” PLoS ONE 12 (1): e0169172. doi:10.1371/journal.pone.0169172. http://dx.doi.org/10.1371/journal.pone.0169172.en
dc.identifier.issn1932-6203en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:30371106
dc.description.abstractRadiomics aims to quantitatively capture the complex tumor phenotype contained in medical images to associate them with clinical outcomes. This study investigates the impact of different types of computed tomography (CT) images on the prognostic performance of radiomic features for disease recurrence in early stage non-small cell lung cancer (NSCLC) patients treated with stereotactic body radiation therapy (SBRT). 112 early stage NSCLC patients treated with SBRT that had static free breathing (FB) and average intensity projection (AIP) images were analyzed. Nineteen radiomic features were selected from each image type (FB or AIP) for analysis based on stability and variance. The selected FB and AIP radiomic feature sets had 6 common radiomic features between both image types and 13 unique features. The prognostic performances of the features for distant metastasis (DM) and locoregional recurrence (LRR) were evaluated using the concordance index (CI) and compared with two conventional features (tumor volume and maximum diameter). P-values were corrected for multiple testing using the false discovery rate procedure. None of the FB radiomic features were associated with DM, however, seven AIP radiomic features, that described tumor shape and heterogeneity, were (CI range: 0.638–0.676). Conventional features from FB images were not associated with DM, however, AIP conventional features were (CI range: 0.643–0.658). Radiomic and conventional multivariate models were compared between FB and AIP images using cross validation. The differences between the models were assessed using a permutation test. AIP radiomic multivariate models (median CI = 0.667) outperformed all other models (median CI range: 0.601–0.630) in predicting DM. None of the imaging features were prognostic of LRR. Therefore, image type impacts the performance of radiomic models in their association with disease recurrence. AIP images contained more information than FB images that were associated with disease recurrence in early stage NSCLC patients treated with SBRT, which suggests that AIP images may potentially be more optimal for the development of an imaging biomarker.en
dc.language.isoen_USen
dc.publisherPublic Library of Scienceen
dc.relation.isversionofdoi:10.1371/journal.pone.0169172en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC5207741/pdf/en
dash.licenseLAAen_US
dc.subjectImaging Techniquesen
dc.subjectNeuroimagingen
dc.subjectComputed Axial Tomographyen
dc.subjectBiology and Life Sciencesen
dc.subjectNeuroscienceen
dc.subjectMedicine and Health Sciencesen
dc.subjectDiagnostic Medicineen
dc.subjectDiagnostic Radiologyen
dc.subjectTomographyen
dc.subjectRadiology and Imagingen
dc.subjectOncologyen
dc.subjectCancer Treatmenten
dc.subjectCancers and Neoplasmsen
dc.subjectLung and Intrathoracic Tumorsen
dc.subjectNon-Small Cell Lung Canceren
dc.subjectPulmonary Imagingen
dc.subjectPhysical Sciencesen
dc.subjectMathematicsen
dc.subjectProbability Theoryen
dc.subjectProbability Distributionen
dc.subjectSkewnessen
dc.subjectRadiation Therapyen
dc.subjectClinical Medicineen
dc.subjectClinical Oncologyen
dc.subjectBiochemistryen
dc.subjectBiomarkersen
dc.titleAssociations of Radiomic Data Extracted from Static and Respiratory-Gated CT Scans with Disease Recurrence in Lung Cancer Patients Treated with SBRTen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalPLoS ONEen
dash.depositing.authorHuynh, Elizabethen_US
dc.date.available2017-02-18T01:59:02Z
dc.identifier.doi10.1371/journal.pone.0169172*
dash.contributor.affiliatedFranco, Idalid
dash.contributor.affiliatedAgrawal, Vishesh
dash.contributor.affiliatedHuynh, Elizabeth
dash.contributor.affiliatedCoroller, Thibaud
dash.contributor.affiliatedParmar, Chintan
dash.contributor.affiliatedAerts, Hugo
dash.contributor.affiliatedMak, Raymond


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