Show simple item record

dc.contributor.authorUygur, Aysuen_US
dc.contributor.authorYoung, Johnen_US
dc.contributor.authorHuycke, Tyler R.en_US
dc.contributor.authorKoska, Mervenazen_US
dc.contributor.authorBriscoe, Jamesen_US
dc.contributor.authorTabin, Clifford J.en_US
dc.date.accessioned2017-02-18T01:59:05Z
dc.date.issued2016en_US
dc.identifier.citationUygur, Aysu, John Young, Tyler R. Huycke, Mervenaz Koska, James Briscoe, and Clifford J. Tabin. 2016. “Scaling Pattern to Variations in Size during Development of the Vertebrate Neural Tube.” Developmental cell 37 (2): 127-135. doi:10.1016/j.devcel.2016.03.024. http://dx.doi.org/10.1016/j.devcel.2016.03.024.en
dc.identifier.issn1534-5807en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:30371113
dc.description.abstractSUMMARY Anatomical proportions are robustly maintained in individuals that vary enormously in size, both within a species and between members of related taxa. However, the mechanisms underlying scaling are still poorly understood. We have examined this phenomenon in the context of the patterning of the ventral neural tube in response to a gradient of the morphogen Sonic hedgehog (SHH) in the chick and zebra finch, two species that differ in size during the time of neural tube patterning. We find that scaling is achieved, at least in part, by altering the sensitivity of the target cells to SHH and appears to be achieved by modulating the ratio of the repressive and activating transcriptional regulators, GLI2 and GLI3. This mechanism contrasts with previous experimental and theoretical analyses of morphogenic scaling that have focused on compensatory changes in the morphogen gradient itself.en
dc.language.isoen_USen
dc.relation.isversionofdoi:10.1016/j.devcel.2016.03.024en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854284/pdf/en
dash.licenseLAAen_US
dc.titleScaling Pattern to Variations in Size during Development of the Vertebrate Neural Tubeen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalDevelopmental cellen
dash.depositing.authorUygur, Aysuen_US
dc.date.available2017-02-18T01:59:05Z
dc.identifier.doi10.1016/j.devcel.2016.03.024*
dash.contributor.affiliatedHuycke, Tyler
dash.contributor.affiliatedYoung, John
dash.contributor.affiliatedUygur, Aysu
dash.contributor.affiliatedTabin, Clifford


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record