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dc.contributor.authorWu, Wentingen_US
dc.contributor.authorLiu, Hongliangen_US
dc.contributor.authorSong, Fengjuen_US
dc.contributor.authorChen, Li-Shiunen_US
dc.contributor.authorKraft, Peteren_US
dc.contributor.authorWei, Qingyien_US
dc.contributor.authorHan, Jialien_US
dc.date.accessioned2017-02-18T01:59:16Z
dc.date.issued2016en_US
dc.identifier.citationWu, Wenting, Hongliang Liu, Fengju Song, Li-Shiun Chen, Peter Kraft, Qingyi Wei, and Jiali Han. 2016. “Associations between smoking behavior-related alleles and the risk of melanoma.” Oncotarget 7 (30): 47366-47375. doi:10.18632/oncotarget.10144. http://dx.doi.org/10.18632/oncotarget.10144.en
dc.identifier.issn1949-2553en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:30371123
dc.description.abstractSeveral studies have reported that cigarette smoking is inversely associated with the risk of melanoma. This study further tested whether incorporating genetic factors will provide another level of evaluation of mechanisms underlying the association between smoking and risk of melanoma. We investigated the association between SNPs selected from genome-wide association studies (GWAS) on smoking behaviors and risk of melanoma using 2,298 melanoma cases and 6,654 controls. Among 16 SNPs, three (rs16969968 [A], rs1051730 [A] and rs2036534 [C] in the 15q25.1 region) reached significance for association with melanoma risk in men (0.01 < = P values < = 0.02; 0.85 < = Odds Ratios (ORs) <= 1.20). There was association between the genetic scores based on the number of smoking behavior-risk alleles and melanoma risk with P-trend = 0.005 among HPFS. Further association with smoking behaviors indicating those three SNPs (rs16969968 [A], rs1051730 [A] and rs2036534 [C]) significantly associated with number of cigarettes smoked per day, CPD, with P = 0.009, 0.011 and 0.001 respectively. The SNPs rs215605 in the PDE1C gene and rs6265 in the BDNF gene significantly interacted with smoking status on melanoma risk (interaction P = 0.005 and P = 0.003 respectively). Our study suggests that smoking behavior-related SNPs are likely to play a role in melanoma development and the potential public health importance of polymorphisms in the CHRNA5-A3-B4 gene cluster. Further larger studies are warranted to validate the findings.en
dc.language.isoen_USen
dc.publisherImpact Journals LLCen
dc.relation.isversionofdoi:10.18632/oncotarget.10144en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216947/pdf/en
dash.licenseLAAen_US
dc.subjectrisk of melanomaen
dc.subjectsmoking behavioren
dc.subjectsingle-nucleotide polymorphisms (SNPs)en
dc.subjectcase-control studyen
dc.subjectCHRNA5-A3-B4 gene clusteren
dc.titleAssociations between smoking behavior-related alleles and the risk of melanomaen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalOncotargeten
dash.depositing.authorKraft, Peteren_US
dc.date.available2017-02-18T01:59:16Z
dc.identifier.doi10.18632/oncotarget.10144*
dash.contributor.affiliatedKraft, Phillip


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