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dc.contributor.authorMenegas, Williamen_US
dc.contributor.authorBabayan, Benedicte Men_US
dc.contributor.authorUchida, Naoshigeen_US
dc.contributor.authorWatabe-Uchida, Mitsukoen_US
dc.date.accessioned2017-02-18T01:59:37Z
dc.date.issued2017en_US
dc.identifier.citationMenegas, William, Benedicte M Babayan, Naoshige Uchida, and Mitsuko Watabe-Uchida. 2017. “Opposite initialization to novel cues in dopamine signaling in ventral and posterior striatum in mice.” eLife 6 (1): e21886. doi:10.7554/eLife.21886. http://dx.doi.org/10.7554/eLife.21886.en
dc.identifier.issn2050-084Xen
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:30371141
dc.description.abstractDopamine neurons are thought to encode novelty in addition to reward prediction error (the discrepancy between actual and predicted values). In this study, we compared dopamine activity across the striatum using fiber fluorometry in mice. During classical conditioning, we observed opposite dynamics in dopamine axon signals in the ventral striatum (‘VS dopamine’) and the posterior tail of the striatum (‘TS dopamine’). TS dopamine showed strong excitation to novel cues, whereas VS dopamine showed no responses to novel cues until they had been paired with a reward. TS dopamine cue responses decreased over time, depending on what the cue predicted. Additionally, TS dopamine showed excitation to several types of stimuli including rewarding, aversive, and neutral stimuli whereas VS dopamine showed excitation only to reward or reward-predicting cues. Together, these results demonstrate that dopamine novelty signals are localized in TS along with general salience signals, while VS dopamine reliably encodes reward prediction error. DOI: http://dx.doi.org/10.7554/eLife.21886.001en
dc.language.isoen_USen
dc.publishereLife Sciences Publications, Ltden
dc.relation.isversionofdoi:10.7554/eLife.21886en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC5271609/pdf/en
dash.licenseLAAen_US
dc.subjectdopamineen
dc.subjectrewarden
dc.subjectnoveltyen
dc.subjectstriatumen
dc.subjectlearningen
dc.subjectMouseen
dc.titleOpposite initialization to novel cues in dopamine signaling in ventral and posterior striatum in miceen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journaleLifeen
dash.depositing.authorMenegas, Williamen_US
dc.date.available2017-02-18T01:59:37Z
dc.identifier.doi10.7554/eLife.21886*
dash.contributor.affiliatedBabayan, Benedicte
dash.contributor.affiliatedMenegas, William
dash.contributor.affiliatedUchida, Naoshige


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