Show simple item record

dc.contributor.authorHulten, Edward A.en_US
dc.contributor.authorBittencourt, Marcio Sommeren_US
dc.contributor.authorPreston, Ryanen_US
dc.contributor.authorSingh, Avinainderen_US
dc.contributor.authorRomagnolli, Carlaen_US
dc.contributor.authorGhoshhajra, Brianen_US
dc.contributor.authorShah, Ravien_US
dc.contributor.authorAbbasi, Siddiqueen_US
dc.contributor.authorAbbara, Suhnyen_US
dc.contributor.authorNasir, Khurramen_US
dc.contributor.authorBlaha, Michaelen_US
dc.contributor.authorHoffmann, Udoen_US
dc.contributor.authorDi Carli, Marcelo F.en_US
dc.contributor.authorBlankstein, Ronen_US
dc.date.accessioned2017-02-18T01:59:58Z
dc.date.issued2017en_US
dc.identifier.citationHulten, E. A., M. S. Bittencourt, R. Preston, A. Singh, C. Romagnolli, B. Ghoshhajra, R. Shah, et al. 2017. “Obesity, metabolic syndrome and cardiovascular prognosis: from the Partners coronary computed tomography angiography registry.” Cardiovascular Diabetology 16 (1): 14. doi:10.1186/s12933-017-0496-8. http://dx.doi.org/10.1186/s12933-017-0496-8.en
dc.identifier.issn1475-2840en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:30371161
dc.description.abstractObjective: To investigate the relationship among body mass index (BMI), cardiometabolic risk and coronary artery disease (CAD) among patients undergoing coronary computed tomography angiography (CTA). Methods: Retrospective cohort study of 1118 patients, who underwent coronary CTA at two centers from September 2004 to October 2011. Coronary CTA were categorized as normal, nonobstructive CAD (<50%), or obstructive CAD (≥50%) in addition to segment involvement (SIS) and stenosis scores. Extensive CAD was defined as SIS > 4. Association of BMI with cardiovascular prognosis was evaluated using multivariable fractional polynomial models. Results: Mean age of the cohort was 57 ± 13 years with median follow-up of 3.2 years. Increasing BMI was associated with MetS (OR 1.28 per 1 kg/m2, p < 0.001) and burden of CAD on a univariable basis, but not after multivariable adjustment. Prognosis demonstrated a J-shaped relationship with BMI. For BMI from 20–39.9 kg/m2, after adjustment for age, gender, and smoking, MetS (HR 2.23, p = 0.009) was more strongly associated with adverse events. Conclusions: Compared to normal BMI, there was an increased burden of CAD for BMI > 25 kg/m2. Within each BMI category, metabolically unhealthy patients had greater extent of CAD, as measured by CCTA, compared to metabolically healthy patients.en
dc.language.isoen_USen
dc.publisherBioMed Centralen
dc.relation.isversionofdoi:10.1186/s12933-017-0496-8en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC5264456/pdf/en
dash.licenseLAAen_US
dc.subjectObesityen
dc.subjectMetabolic syndromeen
dc.subjectCoronary computed tomography angiographyen
dc.subjectCoronary artery diseaseen
dc.subjectPrognosisen
dc.subjectCohorten
dc.titleObesity, metabolic syndrome and cardiovascular prognosis: from the Partners coronary computed tomography angiography registryen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalCardiovascular Diabetologyen
dash.depositing.authorSingh, Avinainderen_US
dc.date.available2017-02-18T01:59:58Z
dc.identifier.doi10.1186/s12933-017-0496-8*
dash.authorsorderedfalse
dash.contributor.affiliatedGhoshhajra, Brian
dash.contributor.affiliatedBlankstein, Ron
dash.contributor.affiliatedShah, Ravi
dash.contributor.affiliatedSingh, Avinainder
dash.contributor.affiliatedHoffmann, Udo
dash.contributor.affiliatedDi Carli, Marcelo


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record