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dc.contributor.authorOh, Hannahen_US
dc.contributor.authorEliassen, A Heatheren_US
dc.contributor.authorWang, Molinen_US
dc.contributor.authorSmith-Warner, Stephanie Aen_US
dc.contributor.authorBeck, Andrew Hen_US
dc.contributor.authorSchnitt, Stuart Jen_US
dc.contributor.authorCollins, Laura Cen_US
dc.contributor.authorConnolly, James Len_US
dc.contributor.authorMontaser-Kouhsari, Lalehen_US
dc.contributor.authorPolyak, Korneliaen_US
dc.contributor.authorTamimi, Rulla Men_US
dc.date.accessioned2017-02-18T02:00:13Z
dc.date.issued2016en_US
dc.identifier.citationOh, H., A. H. Eliassen, M. Wang, S. A. Smith-Warner, A. H. Beck, S. J. Schnitt, L. C. Collins, et al. 2016. “Expression of estrogen receptor, progesterone receptor, and Ki67 in normal breast tissue in relation to subsequent risk of breast cancer.” NPJ breast cancer 2 (1): 16032. doi:10.1038/npjbcancer.2016.32. http://dx.doi.org/10.1038/npjbcancer.2016.32.en
dc.identifier.issn2374-4677en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:30371182
dc.description.abstractAlthough expression of estrogen receptor (ER), progesterone receptor (PR), and cell proliferation marker Ki67 serve as predictive and prognostic factors in breast cancers, little is known about their roles in normal breast tissue. Here in a nested case–control study within the Nurses’ Health Studies (90 cases, 297 controls), we evaluated their expression levels in normal breast epithelium in relation to subsequent breast cancer risk among women with benign breast disease. Tissue microarrays were constructed using cores obtained from benign biopsies containing normal terminal duct lobular units and immunohistochemical stained for these markers. We found PR and Ki67 expression was non-significantly but positively associated with subsequent breast cancer risk, whereas ER expression was non-significantly inversely associated. After stratifying by lesion subtype, Ki67 was significantly associated with higher risk among women with proliferative lesions with atypical hyperplasia. However, given the small sample size, further studies are required to confirm these results.en
dc.language.isoen_USen
dc.relation.isversionofdoi:10.1038/npjbcancer.2016.32en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC5243126/pdf/en
dash.licenseLAAen_US
dc.titleExpression of estrogen receptor, progesterone receptor, and Ki67 in normal breast tissue in relation to subsequent risk of breast canceren
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalNPJ breast canceren
dash.depositing.authorEliassen, A Heatheren_US
dc.date.available2017-02-18T02:00:13Z
dc.identifier.doi10.1038/npjbcancer.2016.32*
dash.authorsorderedfalse
dash.contributor.affiliatedWang, Molin
dash.contributor.affiliatedSmith-Warner, Stephanie
dash.contributor.affiliatedConnolly, James
dash.contributor.affiliatedCollins, Laura
dash.contributor.affiliatedTamimi, Rulla
dash.contributor.affiliatedBeck, Andrew
dash.contributor.affiliatedSchnitt, Stuart
dash.contributor.affiliatedEliassen, A.
dash.contributor.affiliatedPolyak, Kornelia


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