Clinical Sequencing Uncovers Origins and Evolution of Lassa Virus

DSpace/Manakin Repository

Clinical Sequencing Uncovers Origins and Evolution of Lassa Virus

Citable link to this page

 

 
Title: Clinical Sequencing Uncovers Origins and Evolution of Lassa Virus
Author: Sabeti, Pardis Christine
Citation: Andersen, Kristian G., B. Jesse Shapiro, Christian B. Matranga, Rachel Sealfon, Aaron E. Lin, Lina M. Moses, Onikepe A. Folarin, et al. 2015. Clinical Sequencing Uncovers Origins and Evolution of Lassa Virus. Cell 162, no. 4: 738–750. doi:10.1016/j.cell.2015.07.020.
Full Text & Related Files:
Abstract: The 2013-2015 West African epidemic of Ebola virus disease (EVD) reminds us how little is known about biosafety level-4 viruses. Like Ebola virus, Lassa virus (LASV) can cause hemorrhagic fever with high case fatality rates. We generated a genomic catalog of almost 200 LASV sequences from clinical and rodent reservoir samples. We show that whereas the 2013-2015 EVD epidemic is fueled by human-to-human transmissions, LASV infections mainly result from reservoir-to-human infections. We elucidated the spread of LASV across West Africa and show that this migration was accompanied by changes in LASV genome abundance, fatality rates, codon adaptation, and translational efficiency. By investigating intrahost evolution, we found that mutations accumulate in epitopes of viral surface proteins, suggesting selection for immune escape. This catalog will serve as a foundation for the development of vaccines and diagnostics.
Published Version: doi:10.1016/j.cell.2015.07.020
Other Sources: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4537774/
Terms of Use: This article is made available under the terms and conditions applicable to Open Access Policy Articles, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#OAP
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:30510304
Downloads of this work:

Show full Dublin Core record

This item appears in the following Collection(s)

 
 

Search DASH


Advanced Search
 
 

Submitters