Probabilistic adaptation in changing microbial environments

DSpace/Manakin Repository

Probabilistic adaptation in changing microbial environments

Citable link to this page

 

 
Title: Probabilistic adaptation in changing microbial environments
Author: Katz, Yarden; Springer, Michael

Note: Order does not necessarily reflect citation order of authors.

Citation: Katz, Yarden, and Michael Springer. 2016. “Probabilistic Adaptation in Changing Microbial Environments.” PeerJ 4 (December 14): e2716. doi:10.7717/peerj.2716.
Full Text & Related Files:
Abstract: Microbes growing in animal host environments face fluctuations that have elements of both randomness and predictability. In the mammalian gut, fluctuations in nutrient levels and other physiological parameters are structured by the animal host’s behavior, diet, health and microbiota composition. Microbial cells that are able to anticipate these fluctuations by exploiting this structure would likely gain a fitness advantage, by adapting their internal state in advance. We propose that the problem of adaptive growth in these structured changing environments can be viewed as probabilistic inference. We analyze environments that are “meta-changing”: where there are changes in the way the environment fluctuates, governed by a mechanism unobservable to cells. We develop a dynamic Bayesian model of these environments and show that a real-time inference algorithm (particle filtering) for this model can be used as a microbial growth strategy implementable in molecular circuits. The growth strategy suggested by our model outperforms heuristic strategies, and points to a class of algorithms that could support real-time probabilistic inference in natural or synthetic cellular circuits.
Published Version: 10.7717/peerj.2716
Other Sources: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5160922/
Terms of Use: This article is made available under the terms and conditions applicable to Open Access Policy Articles, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#OAP
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:30831905
Downloads of this work:

Show full Dublin Core record

This item appears in the following Collection(s)

 
 

Search DASH


Advanced Search
 
 

Submitters