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dc.contributor.authorEpel, Elissa S.
dc.contributor.authorLin, Jue
dc.contributor.authorWilhelm, Frank H.
dc.contributor.authorWolkowitz, Owen M.
dc.contributor.authorCawthon, Richard
dc.contributor.authorAdler, Nancy E.
dc.contributor.authorDolbier, Christyn
dc.contributor.authorMendes, Wendy
dc.contributor.authorBlackburn, Elizabeth H.
dc.date.accessioned2009-06-30T20:06:12Z
dc.date.issued2006
dc.identifier.citationEpel, Elissa S., Jue Lin, Frank H. Wilhelm, Owen M. Wolkowitz, Richard Cawthon, Nancy E. Adler, Christyn Dolbier, Wendy B. Mendes, and Elizabeth H. Blackburn. 2006. Cell aging in relation to stress arousal and cardiovascular disease risk factors. Psychoneuroendocrinology 31(3): 277-287.en
dc.identifier.issn0306-4530en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:3128692
dc.description.abstractWe previously reported that psychological stress is linked to and possibly accelerates cellular aging, as reflected by tower PBMC telomerase and shortened tetomeres. Psychological stress is a major risk factor for cardiovascular disease (CVD), with multiple behavioral and physiological mediators. Telomere shortness has been associated with CVD, but the relationship between tow telomerase activity, a potential precursor to telomere shortening, and CVD risk factors has not been examined in humans. Here we examine whether telomere length and telomerase in leukocytes are associated with physiological signs of stress arousal and CVD risk factors in 62 healthy women. Low telomerase activity in Leukocytes was associated with exaggerated autonomic reactivity to acute mentat stress and elevated nocturnal epinephrine. Further, tow telomerase activity was associated with the major risk factors for CVD -smoking, poor lipid profile, high systolic blood pressure, high fasting glucose, greater abdominal adiposity-as well as to a composite Metabolic Syndrome variable. Telomere length was related only to elevated stress hormones (catecholamines and cortisol). Thus, we propose that low leukocyte telomerase constitutes an early marker of CVD risk, possibly preceding shortened telomeres, that results in part from chronic stress arousal. Possible cellular mechanisms by which Low telomerase may link stress and traditional risk factors to CVD are discussed. These findings may implicate telomerase as a novel and important mediator of the effects of psychological stress on physical health and disease.en
dc.description.sponsorshipPsychologyen
dc.language.isoen_USen
dc.publisherElsevieren
dc.relation.isversionofhttp://dx.doi.org/10.1016/j.psyneuen.2005.08.011en
dash.licenseLAA
dc.subjectheart rate variabilityen
dc.subjectstress hormonesen
dc.subjecttelomere lengthen
dc.subjectstressen
dc.subjecttelomeraseen
dc.subjectmetabolic syndromeen
dc.titleCell Aging in Relation to Stress Arousal and Cardiovascular Disease Risk Factorsen
dc.typeJournal Article
dc.description.versionVersion of Record
dc.relation.journalPsychoneuroendocrinologyen
dash.depositing.authorMendes, Wendy
dc.identifier.doi10.1016/j.psyneuen.2005.08.011*
dash.contributor.affiliatedMendes, Wendy


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