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dc.contributor.authorWeir, Gordon C.en_US
dc.contributor.authorBonner-Weir, Susanen_US
dc.date.accessioned2017-03-28T23:47:55Z
dc.date.issued2017en_US
dc.identifier.citationWeir, Gordon C., and Susan Bonner-Weir. 2017. “Glucose Driven Changes in Beta Cell Identity Are Important for Function and Possibly Autoimmune Vulnerability during the Progression of Type 1 Diabetes.” Frontiers in Genetics 8 (1): 2. doi:10.3389/fgene.2017.00002. http://dx.doi.org/10.3389/fgene.2017.00002.en
dc.identifier.issnen
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:31731635
dc.description.abstractThis commentary explores the hypothesis that when autoimmunity leads to a fall of beta cell mass during the progression of type 1 diabetes (T1D), rising glucose levels cause major changes in beta cell identity. This then leads to profound changes in secretory function and less well-understood changes in beta cell susceptibility to autoimmune destruction, which may influence of rate of progression of beta cell killing.en
dc.language.isoen_USen
dc.publisherFrontiers Media S.A.en
dc.relation.isversionofdoi:10.3389/fgene.2017.00002en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC5258704/pdf/en
dash.licenseLAAen_US
dc.subjectPerspectiveen
dc.subjectbeta-cell biologyen
dc.subjecttype 1 diabetesen
dc.subjectautoimmunityen
dc.subjectbeta-cell identityen
dc.subjectbeta-cell functionen
dc.titleGlucose Driven Changes in Beta Cell Identity Are Important for Function and Possibly Autoimmune Vulnerability during the Progression of Type 1 Diabetesen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalFrontiers in Geneticsen
dash.depositing.authorWeir, Gordon C.en_US
dc.date.available2017-03-28T23:47:55Z
dc.identifier.doi10.3389/fgene.2017.00002*
dash.contributor.affiliatedBonner-Weir, Susan
dash.contributor.affiliatedWeir, Gordon


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