dc.contributor.author | Weir, Gordon C. | en_US |
dc.contributor.author | Bonner-Weir, Susan | en_US |
dc.date.accessioned | 2017-03-28T23:47:55Z | |
dc.date.issued | 2017 | en_US |
dc.identifier.citation | Weir, Gordon C., and Susan Bonner-Weir. 2017. “Glucose Driven Changes in Beta Cell Identity Are Important for Function and Possibly Autoimmune Vulnerability during the Progression of Type 1 Diabetes.” Frontiers in Genetics 8 (1): 2. doi:10.3389/fgene.2017.00002. http://dx.doi.org/10.3389/fgene.2017.00002. | en |
dc.identifier.issn | | en |
dc.identifier.uri | http://nrs.harvard.edu/urn-3:HUL.InstRepos:31731635 | |
dc.description.abstract | This commentary explores the hypothesis that when autoimmunity leads to a fall of beta cell mass during the progression of type 1 diabetes (T1D), rising glucose levels cause major changes in beta cell identity. This then leads to profound changes in secretory function and less well-understood changes in beta cell susceptibility to autoimmune destruction, which may influence of rate of progression of beta cell killing. | en |
dc.language.iso | en_US | en |
dc.publisher | Frontiers Media S.A. | en |
dc.relation.isversionof | doi:10.3389/fgene.2017.00002 | en |
dc.relation.hasversion | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5258704/pdf/ | en |
dash.license | LAA | en_US |
dc.subject | Perspective | en |
dc.subject | beta-cell biology | en |
dc.subject | type 1 diabetes | en |
dc.subject | autoimmunity | en |
dc.subject | beta-cell identity | en |
dc.subject | beta-cell function | en |
dc.title | Glucose Driven Changes in Beta Cell Identity Are Important for Function and Possibly Autoimmune Vulnerability during the Progression of Type 1 Diabetes | en |
dc.type | Journal Article | en_US |
dc.description.version | Version of Record | en |
dc.relation.journal | Frontiers in Genetics | en |
dash.depositing.author | Weir, Gordon C. | en_US |
dc.date.available | 2017-03-28T23:47:55Z | |
dc.identifier.doi | 10.3389/fgene.2017.00002 | * |
dash.contributor.affiliated | Bonner-Weir, Susan | |
dash.contributor.affiliated | Weir, Gordon | |