Exome and genome sequencing of nasopharynx cancer identifies NF-κB pathway activating mutations

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Exome and genome sequencing of nasopharynx cancer identifies NF-κB pathway activating mutations

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Title: Exome and genome sequencing of nasopharynx cancer identifies NF-κB pathway activating mutations
Author: Li, Yvonne Y; Chung, Grace T. Y.; Lui, Vivian W. Y.; To, Ka-Fai; Ma, Brigette B. Y.; Chow, Chit; Woo, John K, S.; Yip, Kevin Y.; Seo, Jeongsun; Hui, Edwin P.; Mak, Michael K. F.; Rusan, Maria; Chau, Nicole G.; Or, Yvonne Y. Y.; Law, Marcus H. N.; Law, Peggy P. Y.; Liu, Zoey W. Y.; Ngan, Hoi-Lam; Hau, Pok-Man; Verhoeft, Krista R.; Poon, Peony H. Y.; Yoo, Seong-Keun; Shin, Jong-Yeon; Lee, Sau-Dan; Lun, Samantha W. M.; Jia, Lin; Chan, Anthony W. H.; Chan, Jason Y. K.; Lai, Paul B. S.; Fung, Choi-Yi; Hung, Suet-Ting; Wang, Lin; Chang, Ann Margaret V.; Chiosea, Simion I.; Hedberg, Matthew L.; Tsao, Sai-Wah; van Hasselt, Andrew C.; Chan, Anthony T. C.; Grandis, Jennifer R.; Hammerman, Peter S.; Lo, Kwok-Wai

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Citation: Li, Y. Y., G. T. Y. Chung, V. W. Y. Lui, K. To, B. B. Y. Ma, C. Chow, J. K. S. Woo, et al. 2017. “Exome and genome sequencing of nasopharynx cancer identifies NF-κB pathway activating mutations.” Nature Communications 8 (1): 14121. doi:10.1038/ncomms14121. http://dx.doi.org/10.1038/ncomms14121.
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Abstract: Nasopharyngeal carcinoma (NPC) is an aggressive head and neck cancer characterized by Epstein-Barr virus (EBV) infection and dense lymphocyte infiltration. The scarcity of NPC genomic data hinders the understanding of NPC biology, disease progression and rational therapy design. Here we performed whole-exome sequencing (WES) on 111 micro-dissected EBV-positive NPCs, with 15 cases subjected to further whole-genome sequencing (WGS), to determine its mutational landscape. We identified enrichment for genomic aberrations of multiple negative regulators of the NF-κB pathway, including CYLD, TRAF3, NFKBIA and NLRC5, in a total of 41% of cases. Functional analysis confirmed inactivating CYLD mutations as drivers for NPC cell growth. The EBV oncoprotein latent membrane protein 1 (LMP1) functions to constitutively activate NF-κB signalling, and we observed mutual exclusivity among tumours with somatic NF-κB pathway aberrations and LMP1-overexpression, suggesting that NF-κB activation is selected for by both somatic and viral events during NPC pathogenesis.
Published Version: doi:10.1038/ncomms14121
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5253631/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:31731730
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