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dc.contributor.authorPujol, Soniaen_US
dc.contributor.authorCabeen, Ryanen_US
dc.contributor.authorSébille, Sophie B.en_US
dc.contributor.authorYelnik, Jérômeen_US
dc.contributor.authorFrançois, Chantalen_US
dc.contributor.authorFernandez Vidal, Saraen_US
dc.contributor.authorKarachi, Carineen_US
dc.contributor.authorZhao, Yulongen_US
dc.contributor.authorCosgrove, G. Reesen_US
dc.contributor.authorJannin, Pierreen_US
dc.contributor.authorKikinis, Ronen_US
dc.contributor.authorBardinet, Ericen_US
dc.date.accessioned2017-03-28T23:49:23Z
dc.date.issued2017en_US
dc.identifier.citationPujol, S., R. Cabeen, S. B. Sébille, J. Yelnik, C. François, S. Fernandez Vidal, C. Karachi, et al. 2017. “In vivo Exploration of the Connectivity between the Subthalamic Nucleus and the Globus Pallidus in the Human Brain Using Multi-Fiber Tractography.” Frontiers in Neuroanatomy 10 (1): 119. doi:10.3389/fnana.2016.00119. http://dx.doi.org/10.3389/fnana.2016.00119.en
dc.identifier.issnen
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:31731736
dc.description.abstractThe basal ganglia is part of a complex system of neuronal circuits that play a key role in the integration and execution of motor, cognitive and emotional function in the human brain. Parkinson’s disease is a progressive neurological disorder of the motor circuit characterized by tremor, rigidity, and slowness of movement. Deep brain stimulation (DBS) of the subthalamic nucleus and the globus pallidus pars interna provides an efficient treatment to reduce symptoms and levodopa-induced side effects in Parkinson’s disease patients. While the underlying mechanism of action of DBS is still unknown, the potential modulation of white matter tracts connecting the surgical targets has become an active area of research. With the introduction of advanced diffusion MRI acquisition sequences and sophisticated post-processing techniques, the architecture of the human brain white matter can be explored in vivo. The goal of this study is to investigate the white matter connectivity between the subthalamic nucleus and the globus pallidus. Two multi-fiber tractography methods were used to reconstruct pallido-subthalamic, subthalamo-pallidal and pyramidal fibers in five healthy subjects datasets of the Human Connectome Project. The anatomical accuracy of the tracts was assessed by four judges with expertise in neuroanatomy, functional neurosurgery, and diffusion MRI. The variability among subjects was evaluated based on the fractional anisotropy and mean diffusivity of the tracts. Both multi-fiber approaches enabled the detection of complex fiber architecture in the basal ganglia. The qualitative evaluation by experts showed that the identified tracts were in agreement with the expected anatomy. Tract-derived measurements demonstrated relatively low variability among subjects. False-negative tracts demonstrated the current limitations of both methods for clinical decision-making. Multi-fiber tractography methods combined with state-of-the-art diffusion MRI data have the potential to help identify white matter tracts connecting DBS targets in functional neurosurgery intervention.en
dc.language.isoen_USen
dc.publisherFrontiers Media S.A.en
dc.relation.isversionofdoi:10.3389/fnana.2016.00119en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC5243825/pdf/en
dash.licenseLAAen_US
dc.subjectdiffusion MRIen
dc.subjectsubthalamic nucleusen
dc.subjectglobus pallidusen
dc.subjectmulti-fiber tractographyen
dc.subjectdeep brain stimulationen
dc.subjecthuman neuroanatomyen
dc.titleIn vivo Exploration of the Connectivity between the Subthalamic Nucleus and the Globus Pallidus in the Human Brain Using Multi-Fiber Tractographyen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalFrontiers in Neuroanatomyen
dash.depositing.authorPujol, Soniaen_US
dc.date.available2017-03-28T23:49:23Z
dc.identifier.doi10.3389/fnana.2016.00119*
dash.authorsorderedfalse
dash.contributor.affiliatedPujol, Sonia
dash.contributor.affiliatedKikinis, Ron
dc.identifier.orcid0000-0001-7227-7058


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