Malignant adenohypophysis spindle cell oncocytoma with repeating recurrences and a high Ki-67 index
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Li, Dongmei
Kong, Yanguo
Zhong, Dingrong
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https://doi.org/10.1097/MD.0000000000005657Metadata
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Kong, Xiangyi, Dongmei Li, Yanguo Kong, and Dingrong Zhong. 2017. “Malignant adenohypophysis spindle cell oncocytoma with repeating recurrences and a high Ki-67 index.” Medicine 96 (4): e5657. doi:10.1097/MD.0000000000005657. http://dx.doi.org/10.1097/MD.0000000000005657.Abstract
Abstract Adenohypophysis spindle cell oncocytoma (ASCO) is a rare tumor recently reported by Roncaroli et al in 2002. This tumor is considered a grade I tumor by the World Health Organization. We report a rare case of malignant ASCO with repeating recurrences and a high Ki-67 index—a challenging diagnosis guided by clinical presentations, radiological signs, and postoperative pathological tests. We represent a 30-year-old man who had suffered from headaches, diplopia, and impaired visual field and acuity. His magnetic resonance imaging revealed an abnormal sellar mass and was originally misdiagnosed as a pituitary macroadenoma. We present detailed analysis of the patient's disease course and review relevant literature. When surgically treated, the specimen revealed a typical histopathology pattern of ASCO. The tumor recurred for several times and the patient underwent 3 surgeries and 1 γ-knife treatment, which was accompanied by a continuously increasing Ki-67 index. This is the first reported case of malignant ASCO (WHO III–IV grade). Despite its rarity, ASCO should be considered in the differential diagnosis of sellar lesions that mimic pituitary adenomas.Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5287946/pdf/Terms of Use
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