dc.contributor.author | Kong, Xiangyi | en_US |
dc.contributor.author | Li, Dongmei | en_US |
dc.contributor.author | Kong, Yanguo | en_US |
dc.contributor.author | Zhong, Dingrong | en_US |
dc.date.accessioned | 2017-03-28T23:49:54Z | |
dc.date.issued | 2017 | en_US |
dc.identifier.citation | Kong, Xiangyi, Dongmei Li, Yanguo Kong, and Dingrong Zhong. 2017. “Malignant adenohypophysis spindle cell oncocytoma with repeating recurrences and a high Ki-67 index.” Medicine 96 (4): e5657. doi:10.1097/MD.0000000000005657. http://dx.doi.org/10.1097/MD.0000000000005657. | en |
dc.identifier.issn | | en |
dc.identifier.uri | http://nrs.harvard.edu/urn-3:HUL.InstRepos:31731769 | |
dc.description.abstract | Abstract Adenohypophysis spindle cell oncocytoma (ASCO) is a rare tumor recently reported by Roncaroli et al in 2002. This tumor is considered a grade I tumor by the World Health Organization. We report a rare case of malignant ASCO with repeating recurrences and a high Ki-67 index—a challenging diagnosis guided by clinical presentations, radiological signs, and postoperative pathological tests. We represent a 30-year-old man who had suffered from headaches, diplopia, and impaired visual field and acuity. His magnetic resonance imaging revealed an abnormal sellar mass and was originally misdiagnosed as a pituitary macroadenoma. We present detailed analysis of the patient's disease course and review relevant literature. When surgically treated, the specimen revealed a typical histopathology pattern of ASCO. The tumor recurred for several times and the patient underwent 3 surgeries and 1 γ-knife treatment, which was accompanied by a continuously increasing Ki-67 index. This is the first reported case of malignant ASCO (WHO III–IV grade). Despite its rarity, ASCO should be considered in the differential diagnosis of sellar lesions that mimic pituitary adenomas. | en |
dc.language.iso | en_US | en |
dc.relation.isversionof | doi:10.1097/MD.0000000000005657 | en |
dc.relation.hasversion | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5287946/pdf/ | en |
dash.license | LAA | en_US |
dc.subject | Observational Study | en |
dc.subject | adenohypophysis spindle cell oncocytoma | en |
dc.subject | Ki-67 index | en |
dc.subject | malignant | en |
dc.subject | recurrent | en |
dc.title | Malignant adenohypophysis spindle cell oncocytoma with repeating recurrences and a high Ki-67 index | en |
dc.type | Journal Article | en_US |
dc.description.version | Version of Record | en |
dc.relation.journal | Medicine | en |
dash.depositing.author | Kong, Xiangyi | en_US |
dc.date.available | 2017-03-28T23:49:54Z | |
dc.identifier.doi | 10.1097/MD.0000000000005657 | * |
dash.authorsordered | false | |
dash.contributor.affiliated | Kong, Xiangyi | |