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dc.contributor.authorHenry, Everett K.en_US
dc.contributor.authorSy, Chandler B.en_US
dc.contributor.authorInclan-Rico, Juan M.en_US
dc.contributor.authorEspinosa, Vanessaen_US
dc.contributor.authorGhanny, Saleena S.en_US
dc.contributor.authorDwyer, Daniel F.en_US
dc.contributor.authorSoteropoulos, Patriciaen_US
dc.contributor.authorRivera, Amarilizen_US
dc.contributor.authorSiracusa, Mark C.en_US
dc.date.accessioned2017-03-28T23:50:03Z
dc.date.issued2016en_US
dc.identifier.citationHenry, Everett K., Chandler B. Sy, Juan M. Inclan-Rico, Vanessa Espinosa, Saleena S. Ghanny, Daniel F. Dwyer, Patricia Soteropoulos, Amariliz Rivera, and Mark C. Siracusa. 2016. “Carbonic anhydrase enzymes regulate mast cell–mediated inflammation.” The Journal of Experimental Medicine 213 (9): 1663-1673. doi:10.1084/jem.20151739. http://dx.doi.org/10.1084/jem.20151739.en
dc.identifier.issnen
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:31731781
dc.description.abstractType 2 cytokine responses are necessary for the development of protective immunity to helminth parasites but also cause the inflammation associated with allergies and asthma. Recent studies have found that peripheral hematopoietic progenitor cells contribute to type 2 cytokine–mediated inflammation through their enhanced ability to develop into mast cells. In this study, we show that carbonic anhydrase (Car) enzymes are up-regulated in type 2–associated progenitor cells and demonstrate that Car enzyme inhibition is sufficient to prevent mouse mast cell responses and inflammation after Trichinella spiralis infection or the induction of food allergy–like disease. Further, we used CRISPR/Cas9 technology and illustrate that genetically editing Car1 is sufficient to selectively reduce mast cell development. Finally, we demonstrate that Car enzymes can be targeted to prevent human mast cell development. Collectively, these experiments identify a previously unrecognized role for Car enzymes in regulating mast cell lineage commitment and suggest that Car enzyme inhibitors may possess therapeutic potential that can be used to treat mast cell–mediated inflammation.en
dc.language.isoen_USen
dc.publisherThe Rockefeller University Pressen
dc.relation.isversionofdoi:10.1084/jem.20151739en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4995079/pdf/en
dash.licenseLAAen_US
dc.subjectBrief Definitive Reporten
dc.titleCarbonic anhydrase enzymes regulate mast cell–mediated inflammationen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalThe Journal of Experimental Medicineen
dash.depositing.authorDwyer, Daniel F.en_US
dc.date.available2017-03-28T23:50:03Z
dc.identifier.doi10.1084/jem.20151739*
dash.contributor.affiliatedDwyer, Daniel


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