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dc.contributor.authorMöhler, Hannsen_US
dc.contributor.authorRudolph, Uween_US
dc.date.accessioned2017-03-28T23:50:18Z
dc.date.issued2017en_US
dc.identifier.citationMöhler, Hanns, and Uwe Rudolph. 2017. “Disinhibition, an emerging pharmacology of learning and memory.” F1000Research 6 (1): F1000 Faculty Rev-101. doi:10.12688/f1000research.9947.1. http://dx.doi.org/10.12688/f1000research.9947.1.en
dc.identifier.issnen
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:31731798
dc.description.abstractLearning and memory are dependent on interactive excitatory and inhibitory mechanisms. In this review, we discuss a mechanism called disinhibition, which is the release of an inhibitory constraint that effectively results in an increased activity in the target neurons (for example, principal or projection neurons). We focus on discussing the role of disinhibition in learning and memory at a basic level and in disease models with cognitive deficits and highlight a strategy to reverse cognitive deficits caused by excess inhibition, through disinhibition of α5-containing GABA A receptors mediating tonic inhibition in the hippocampus, based on subtype-selective negative allosteric modulators as a novel class of drugs.en
dc.language.isoen_USen
dc.publisherF1000Researchen
dc.relation.isversionofdoi:10.12688/f1000research.9947.1en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC5302145/pdf/en
dash.licenseLAAen_US
dc.subjectArticlesen
dc.subjectCognitive Neuroscienceen
dc.subjectMedical Geneticsen
dc.subjectMolecular Pharmacologyen
dc.subjectNeurobiology of Disease & Regenerationen
dc.subjectNeuronal Signaling Mechanismsen
dc.subjectNeuropharmacology & Psychopharmacologyen
dc.subjectPavlovian learningen
dc.subjectdisinhibitionen
dc.subjectsomatostatinen
dc.subjectGABAAen
dc.subjectallosteric modulatorsen
dc.titleDisinhibition, an emerging pharmacology of learning and memoryen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalF1000Researchen
dash.depositing.authorRudolph, Uween_US
dc.date.available2017-03-28T23:50:18Z
dc.identifier.doi10.12688/f1000research.9947.1*
dash.contributor.affiliatedRudolph, Uwe


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