dc.contributor.author | Mathew, Rebecca S | en_US |
dc.contributor.author | Tatarakis, Antonis | en_US |
dc.contributor.author | Rudenko, Andrii | en_US |
dc.contributor.author | Johnson-Venkatesh, Erin M | en_US |
dc.contributor.author | Yang, Yawei J | en_US |
dc.contributor.author | Murphy, Elisabeth A | en_US |
dc.contributor.author | Todd, Travis P | en_US |
dc.contributor.author | Schepers, Scott T | en_US |
dc.contributor.author | Siuti, Nertila | en_US |
dc.contributor.author | Martorell, Anthony J | en_US |
dc.contributor.author | Falls, William A | en_US |
dc.contributor.author | Hammack, Sayamwong E | en_US |
dc.contributor.author | Walsh, Christopher A | en_US |
dc.contributor.author | Tsai, Li-Huei | en_US |
dc.contributor.author | Umemori, Hisashi | en_US |
dc.contributor.author | Bouton, Mark E | en_US |
dc.contributor.author | Moazed, Danesh | en_US |
dc.date.accessioned | 2017-03-28T23:50:49Z | |
dc.date.issued | 2016 | en_US |
dc.identifier.citation | Mathew, R. S., A. Tatarakis, A. Rudenko, E. M. Johnson-Venkatesh, Y. J. Yang, E. A. Murphy, T. P. Todd, et al. 2016. “A microRNA negative feedback loop downregulates vesicle transport and inhibits fear memory.” eLife 5 (1): e22467. doi:10.7554/eLife.22467. http://dx.doi.org/10.7554/eLife.22467. | en |
dc.identifier.issn | | en |
dc.identifier.uri | http://nrs.harvard.edu/urn-3:HUL.InstRepos:31731816 | |
dc.description.abstract | The SNARE-mediated vesicular transport pathway plays major roles in synaptic remodeling associated with formation of long-term memories, but the mechanisms that regulate this pathway during memory acquisition are not fully understood. Here we identify miRNAs that are up-regulated in the rodent hippocampus upon contextual fear-conditioning and identify the vesicular transport and synaptogenesis pathways as the major targets of the fear-induced miRNAs. We demonstrate that miR-153, a member of this group, inhibits the expression of key components of the vesicular transport machinery, and down-regulates Glutamate receptor A1 trafficking and neurotransmitter release. MiR-153 expression is specifically induced during LTP induction in hippocampal slices and its knockdown in the hippocampus of adult mice results in enhanced fear memory. Our results suggest that miR-153, and possibly other fear-induced miRNAs, act as components of a negative feedback loop that blocks neuronal hyperactivity at least partly through the inhibition of the vesicular transport pathway. DOI: http://dx.doi.org/10.7554/eLife.22467.001 | en |
dc.language.iso | en_US | en |
dc.publisher | eLife Sciences Publications, Ltd | en |
dc.relation.isversionof | doi:10.7554/eLife.22467 | en |
dc.relation.hasversion | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5293492/pdf/ | en |
dash.license | LAA | en_US |
dc.subject | learning | en |
dc.subject | memory | en |
dc.subject | synaptic plasticity | en |
dc.subject | miRNA | en |
dc.subject | hippocampus | en |
dc.subject | negative feed back loop | en |
dc.subject | Rat | en |
dc.subject | Mouse | en |
dc.title | A microRNA negative feedback loop downregulates vesicle transport and inhibits fear memory | en |
dc.type | Journal Article | en_US |
dc.description.version | Version of Record | en |
dc.relation.journal | eLife | en |
dash.depositing.author | Mathew, Rebecca S | en_US |
dc.date.available | 2017-03-28T23:50:49Z | |
dc.identifier.doi | 10.7554/eLife.22467 | * |
dash.authorsordered | false | |
dash.contributor.affiliated | Tatarakis, Antonis | |
dash.contributor.affiliated | Umemori, Hisashi | |
dash.contributor.affiliated | Mathew, Rebecca S | |
dash.contributor.affiliated | Walsh, Christopher | |
dash.contributor.affiliated | Moazed, Danesh | |