Repetitive head impact exposure and later-life plasma total tau in former National Football League players

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Repetitive head impact exposure and later-life plasma total tau in former National Football League players

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Title: Repetitive head impact exposure and later-life plasma total tau in former National Football League players
Author: Alosco, Michael L.; Tripodis, Yorghos; Jarnagin, Johnny; Baugh, Christine M.; Martin, Brett; Chaisson, Christine E.; Estochen, Nate; Song, Linan; Cantu, Robert C.; Jeromin, Andreas; Stern, Robert A.

Note: Order does not necessarily reflect citation order of authors.

Citation: Alosco, M. L., Y. Tripodis, J. Jarnagin, C. M. Baugh, B. Martin, C. E. Chaisson, N. Estochen, et al. 2016. “Repetitive head impact exposure and later-life plasma total tau in former National Football League players.” Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring 7 (1): 33-40. doi:10.1016/j.dadm.2016.11.003. http://dx.doi.org/10.1016/j.dadm.2016.11.003.
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Abstract: Introduction: Blood protein analysis of total tau (t-tau) may be a practical screening biomarker for chronic traumatic encephalopathy (CTE), a neurodegenerative tauopathy associated with repetitive head impact (RHI) exposure. We examined plasma t-tau in symptomatic former National Football League (NFL) players compared with controls and the relationship between RHI exposure and later-life plasma t-tau. Methods: Ninety-six former NFL players (age 40–69) and 25 same-age controls underwent blood draw to determine plasma t-tau levels. The cumulative head impact index (CHII) quantified RHI exposure. Subjects completed measures of clinical function. Results: A higher CHII predicted greater plasma t-tau in the former NFL players (P = .0137). No group differences in plasma t-tau emerged, but a concentration ≥3.56 pg/mL was 100% specific to former NFL players. Plasma t-tau did not predict clinical function. Discussion Greater RHI exposure predicted higher later-life plasma t-tau concentrations, and further study on plasma t-tau as a candidate screening biomarker for CTE is warranted.
Published Version: doi:10.1016/j.dadm.2016.11.003
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5312499/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:31731825
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