Global and local selection acting on the pathogen Stenotrophomonas maltophilia in the human lung

DSpace/Manakin Repository

Global and local selection acting on the pathogen Stenotrophomonas maltophilia in the human lung

Citable link to this page

 

 
Title: Global and local selection acting on the pathogen Stenotrophomonas maltophilia in the human lung
Author: Chung, Hattie; Lieberman, Tami D.; Vargas, Sara O.; Flett, Kelly B.; McAdam, Alexander J.; Priebe, Gregory P.; Kishony, Roy

Note: Order does not necessarily reflect citation order of authors.

Citation: Chung, Hattie, Tami D. Lieberman, Sara O. Vargas, Kelly B. Flett, Alexander J. McAdam, Gregory P. Priebe, and Roy Kishony. 2017. “Global and local selection acting on the pathogen Stenotrophomonas maltophilia in the human lung.” Nature Communications 8 (1): 14078. doi:10.1038/ncomms14078. http://dx.doi.org/10.1038/ncomms14078.
Full Text & Related Files:
Abstract: Bacterial populations diversify during infection into distinct subpopulations that coexist within the human body. Yet, it is unknown to what extent subpopulations adapt to location-specific selective pressures as they migrate and evolve across space. Here we identify bacterial genes under local and global selection by testing for spatial co-occurrence of adaptive mutations. We sequence 552 genomes of the pathogen Stenotrophomonas maltophilia across 23 sites of the lungs from a patient with cystic fibrosis. We show that although genetically close isolates colocalize in space, distant lineages with distinct phenotypes separated by adaptive mutations spread throughout the lung, suggesting global selective pressures. Yet, for one gene (a distant homologue of the merC gene implicated in metal resistance), mutations arising independently in two lineages colocalize in space, providing evidence for location-specific selection. Our work presents a general framework for understanding how selection acts upon a pathogen that colonizes and evolves across the complex environment of the human body.
Published Version: doi:10.1038/ncomms14078
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5253648/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:31731826
Downloads of this work:

Show full Dublin Core record

This item appears in the following Collection(s)

 
 

Search DASH


Advanced Search
 
 

Submitters