Nasal neuron PET imaging quantifies neuron generation and degeneration

DSpace/Manakin Repository

Nasal neuron PET imaging quantifies neuron generation and degeneration

Citable link to this page


Title: Nasal neuron PET imaging quantifies neuron generation and degeneration
Author: Van de Bittner, Genevieve C.; Riley, Misha M.; Cao, Luxiang; Ehses, Janina; Herrick, Scott P.; Ricq, Emily L.; Wey, Hsiao-Ying; O’Neill, Michael J.; Ahmed, Zeshan; Murray, Tracey K.; Smith, Jaclyn E.; Wang, Changning; Schroeder, Frederick A.; Albers, Mark W.; Hooker, Jacob M.

Note: Order does not necessarily reflect citation order of authors.

Citation: Van de Bittner, G. C., M. M. Riley, L. Cao, J. Ehses, S. P. Herrick, E. L. Ricq, H. Wey, et al. 2017. “Nasal neuron PET imaging quantifies neuron generation and degeneration.” The Journal of Clinical Investigation 127 (2): 681-694. doi:10.1172/JCI89162.
Full Text & Related Files:
Abstract: Olfactory dysfunction is broadly associated with neurodevelopmental and neurodegenerative diseases and predicts increased mortality rates in healthy individuals. Conventional measurements of olfactory health assess odor processing pathways within the brain and provide a limited understanding of primary odor detection. Quantification of the olfactory sensory neurons (OSNs), which detect odors within the nasal cavity, would provide insight into the etiology of olfactory dysfunction associated with disease and mortality. Notably, OSNs are continually replenished by adult neurogenesis in mammals, including humans, so OSN measurements are primed to provide specialized insights into neurological disease. Here, we have evaluated a PET radiotracer, [11C]GV1-57, that specifically binds mature OSNs and quantifies the mature OSN population in vivo. [11C]GV1-57 monitored native OSN population dynamics in rodents, detecting OSN generation during postnatal development and aging-associated neurodegeneration. [11C]GV1-57 additionally measured rates of neuron regeneration after acute injury and early-stage OSN deficits in a rodent tauopathy model of neurodegenerative disease. Preliminary assessment in nonhuman primates suggested maintained uptake and saturable binding of [18F]GV1-57 in primate nasal epithelium, supporting its translational potential. Future applications for GV1-57 include monitoring additional diseases or conditions associated with olfactory dysregulation, including cognitive decline, as well as monitoring effects of neuroregenerative or neuroprotective therapeutics.
Published Version: doi:10.1172/JCI89162
Other Sources:
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at
Citable link to this page:
Downloads of this work:

Show full Dublin Core record

This item appears in the following Collection(s)


Search DASH

Advanced Search