Serotonin-dependent kinetics of feeding bursts underlie a graded response to food availability in C. elegans

DSpace/Manakin Repository

Serotonin-dependent kinetics of feeding bursts underlie a graded response to food availability in C. elegans

Citable link to this page

 

 
Title: Serotonin-dependent kinetics of feeding bursts underlie a graded response to food availability in C. elegans
Author: Lee, Kyung Suk; Iwanir, Shachar; Kopito, Ronen B.; Scholz, Monika; Calarco, John A.; Biron, David; Levine, Erel

Note: Order does not necessarily reflect citation order of authors.

Citation: Lee, Kyung Suk, Shachar Iwanir, Ronen B. Kopito, Monika Scholz, John A. Calarco, David Biron, and Erel Levine. 2017. “Serotonin-dependent kinetics of feeding bursts underlie a graded response to food availability in C. elegans.” Nature Communications 8 (1): 14221. doi:10.1038/ncomms14221. http://dx.doi.org/10.1038/ncomms14221.
Full Text & Related Files:
Abstract: Animals integrate physiological and environmental signals to modulate their food uptake. The nematode C. elegans, whose food uptake consists of pumping bacteria from the environment into the gut, provides excellent opportunities for discovering principles of conserved regulatory mechanisms. Here we show that worms implement a graded feeding response to the concentration of environmental bacteria by modulating a commitment to bursts of fast pumping. Using long-term, high-resolution, longitudinal recordings of feeding dynamics under defined conditions, we find that the frequency and duration of pumping bursts increase and the duration of long pauses diminishes in environments richer in bacteria. The bioamine serotonin is required for food-dependent induction of bursts as well as for maintaining their high rate of pumping through two distinct mechanisms. We identify the differential roles of distinct families of serotonin receptors in this process and propose that regulation of bursts is a conserved mechanism of behaviour and motor control.
Published Version: doi:10.1038/ncomms14221
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5296638/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:31731873
Downloads of this work:

Show full Dublin Core record

This item appears in the following Collection(s)

 
 

Search DASH


Advanced Search
 
 

Submitters