Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia
dc.contributor.author | Law, Philip J. | en_US |
dc.contributor.author | Berndt, Sonja I. | en_US |
dc.contributor.author | Speedy, Helen E. | en_US |
dc.contributor.author | Camp, Nicola J. | en_US |
dc.contributor.author | Sava, Georgina P. | en_US |
dc.contributor.author | Skibola, Christine F. | en_US |
dc.contributor.author | Holroyd, Amy | en_US |
dc.contributor.author | Joseph, Vijai | en_US |
dc.contributor.author | Sunter, Nicola J. | en_US |
dc.contributor.author | Nieters, Alexandra | en_US |
dc.contributor.author | Bea, Silvia | en_US |
dc.contributor.author | Monnereau, Alain | en_US |
dc.contributor.author | Martin-Garcia, David | en_US |
dc.contributor.author | Goldin, Lynn R. | en_US |
dc.contributor.author | Clot, Guillem | en_US |
dc.contributor.author | Teras, Lauren R. | en_US |
dc.contributor.author | Quintela, Inés | en_US |
dc.contributor.author | Birmann, Brenda M. | en_US |
dc.contributor.author | Jayne, Sandrine | en_US |
dc.contributor.author | Cozen, Wendy | en_US |
dc.contributor.author | Majid, Aneela | en_US |
dc.contributor.author | Smedby, Karin E. | en_US |
dc.contributor.author | Lan, Qing | en_US |
dc.contributor.author | Dearden, Claire | en_US |
dc.contributor.author | Brooks-Wilson, Angela R. | en_US |
dc.contributor.author | Hall, Andrew G. | en_US |
dc.contributor.author | Purdue, Mark P. | en_US |
dc.contributor.author | Mainou-Fowler, Tryfonia | en_US |
dc.contributor.author | Vajdic, Claire M. | en_US |
dc.contributor.author | Jackson, Graham H. | en_US |
dc.contributor.author | Cocco, Pierluigi | en_US |
dc.contributor.author | Marr, Helen | en_US |
dc.contributor.author | Zhang, Yawei | en_US |
dc.contributor.author | Zheng, Tongzhang | en_US |
dc.contributor.author | Giles, Graham G. | en_US |
dc.contributor.author | Lawrence, Charles | en_US |
dc.contributor.author | Call, Timothy G. | en_US |
dc.contributor.author | Liebow, Mark | en_US |
dc.contributor.author | Melbye, Mads | en_US |
dc.contributor.author | Glimelius, Bengt | en_US |
dc.contributor.author | Mansouri, Larry | en_US |
dc.contributor.author | Glenn, Martha | en_US |
dc.contributor.author | Curtin, Karen | en_US |
dc.contributor.author | Diver, W Ryan | en_US |
dc.contributor.author | Link, Brian K. | en_US |
dc.contributor.author | Conde, Lucia | en_US |
dc.contributor.author | Bracci, Paige M. | en_US |
dc.contributor.author | Holly, Elizabeth A. | en_US |
dc.contributor.author | Jackson, Rebecca D. | en_US |
dc.contributor.author | Tinker, Lesley F. | en_US |
dc.contributor.author | Benavente, Yolanda | en_US |
dc.contributor.author | Boffetta, Paolo | en_US |
dc.contributor.author | Brennan, Paul | en_US |
dc.contributor.author | Maynadie, Marc | en_US |
dc.contributor.author | McKay, James | en_US |
dc.contributor.author | Albanes, Demetrius | en_US |
dc.contributor.author | Weinstein, Stephanie | en_US |
dc.contributor.author | Wang, Zhaoming | en_US |
dc.contributor.author | Caporaso, Neil E. | en_US |
dc.contributor.author | Morton, Lindsay M. | en_US |
dc.contributor.author | Severson, Richard K. | en_US |
dc.contributor.author | Riboli, Elio | en_US |
dc.contributor.author | Vineis, Paolo | en_US |
dc.contributor.author | Vermeulen, Roel C. H. | en_US |
dc.contributor.author | Southey, Melissa C. | en_US |
dc.contributor.author | Milne, Roger L. | en_US |
dc.contributor.author | Clavel, Jacqueline | en_US |
dc.contributor.author | Topka, Sabine | en_US |
dc.contributor.author | Spinelli, John J. | en_US |
dc.contributor.author | Kraft, Peter | en_US |
dc.contributor.author | Ennas, Maria Grazia | en_US |
dc.contributor.author | Summerfield, Geoffrey | en_US |
dc.contributor.author | Ferri, Giovanni M. | en_US |
dc.contributor.author | Harris, Robert J. | en_US |
dc.contributor.author | Miligi, Lucia | en_US |
dc.contributor.author | Pettitt, Andrew R. | en_US |
dc.contributor.author | North, Kari E. | en_US |
dc.contributor.author | Allsup, David J. | en_US |
dc.contributor.author | Fraumeni, Joseph F. | en_US |
dc.contributor.author | Bailey, James R. | en_US |
dc.contributor.author | Offit, Kenneth | en_US |
dc.contributor.author | Pratt, Guy | en_US |
dc.contributor.author | Hjalgrim, Henrik | en_US |
dc.contributor.author | Pepper, Chris | en_US |
dc.contributor.author | Chanock, Stephen J. | en_US |
dc.contributor.author | Fegan, Chris | en_US |
dc.contributor.author | Rosenquist, Richard | en_US |
dc.contributor.author | de Sanjose, Silvia | en_US |
dc.contributor.author | Carracedo, Angel | en_US |
dc.contributor.author | Dyer, Martin J. S. | en_US |
dc.contributor.author | Catovsky, Daniel | en_US |
dc.contributor.author | Campo, Elias | en_US |
dc.contributor.author | Cerhan, James R. | en_US |
dc.contributor.author | Allan, James M. | en_US |
dc.contributor.author | Rothman, Nathanial | en_US |
dc.contributor.author | Houlston, Richard | en_US |
dc.contributor.author | Slager, Susan | en_US |
dc.date.accessioned | 2017-03-28T23:52:28Z | |
dc.date.issued | 2017 | en_US |
dc.identifier.citation | Law, P. J., S. I. Berndt, H. E. Speedy, N. J. Camp, G. P. Sava, C. F. Skibola, A. Holroyd, et al. 2017. “Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia.” Nature Communications 8 (1): 14175. doi:10.1038/ncomms14175. http://dx.doi.org/10.1038/ncomms14175. | en |
dc.identifier.issn | en | |
dc.identifier.uri | http://nrs.harvard.edu/urn-3:HUL.InstRepos:31731882 | |
dc.description.abstract | Several chronic lymphocytic leukaemia (CLL) susceptibility loci have been reported; however, much of the heritable risk remains unidentified. Here we perform a meta-analysis of six genome-wide association studies, imputed using a merged reference panel of 1,000 Genomes and UK10K data, totalling 6,200 cases and 17,598 controls after replication. We identify nine risk loci at 1p36.11 (rs34676223, P=5.04 × 10−13), 1q42.13 (rs41271473, P=1.06 × 10−10), 4q24 (rs71597109, P=1.37 × 10−10), 4q35.1 (rs57214277, P=3.69 × 10−8), 6p21.31 (rs3800461, P=1.97 × 10−8), 11q23.2 (rs61904987, P=2.64 × 10−11), 18q21.1 (rs1036935, P=3.27 × 10−8), 19p13.3 (rs7254272, P=4.67 × 10−8) and 22q13.33 (rs140522, P=2.70 × 10−9). These new and established risk loci map to areas of active chromatin and show an over-representation of transcription factor binding for the key determinants of B-cell development and immune response. | en |
dc.language.iso | en_US | en |
dc.publisher | Nature Publishing Group | en |
dc.relation.isversionof | doi:10.1038/ncomms14175 | en |
dc.relation.hasversion | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5303820/pdf/ | en |
dash.license | LAA | en_US |
dc.title | Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia | en |
dc.type | Journal Article | en_US |
dc.description.version | Version of Record | en |
dc.relation.journal | Nature Communications | en |
dash.depositing.author | Birmann, Brenda M. | en_US |
dc.date.available | 2017-03-28T23:52:28Z | |
dc.identifier.doi | 10.1038/ncomms14175 | * |
dash.authorsordered | false | |
dash.contributor.affiliated | Birmann, Brenda | |
dash.contributor.affiliated | Kraft, Phillip |
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