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dc.contributor.authorGeorgette, Nathanen_US
dc.contributor.authorSiedner, Mark J.en_US
dc.contributor.authorPetty, Carter R.en_US
dc.contributor.authorZanoni, Brian C.en_US
dc.contributor.authorCarpenter, Stephenen_US
dc.contributor.authorHaberer, Jessica E.en_US
dc.date.accessioned2017-03-28T23:52:32Z
dc.date.issued2017en_US
dc.identifier.citationGeorgette, Nathan, Mark J. Siedner, Carter R. Petty, Brian C. Zanoni, Stephen Carpenter, and Jessica E. Haberer. 2017. “Impact of a clinical program using weekly Short Message Service (SMS) on antiretroviral therapy adherence support in South Africa: a retrospective cohort study.” BMC Medical Informatics and Decision Making 17 (1): 18. doi:10.1186/s12911-017-0413-9. http://dx.doi.org/10.1186/s12911-017-0413-9.en
dc.identifier.issnen
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:31731889
dc.description.abstractBackground: In randomized controlled trials, short message service (SMS) programs have improved adherence to HIV antiretroviral therapy (ART). In response, the World Health Organization recommended use of SMS programs to support ART. However, there is limited data on real-world implementations of SMS programs. Methods: We conducted a retrospective cohort study of an SMS program to improve ART adherence in a government-run HIV clinic in rural South Africa. We analyzed data from all adult patients who 1) enrolled at the clinic before the observation period (July 2013 through June 2014), 2) had ≥1 ART prescriptions in the observation period, and 3) had data on phone number availability (N = 2255). Our main outcome measure was prescription coverage, defined as the presence of a valid ART prescription for each day observed. We fit generalized linear mixed models adjusted for pre-program prescription coverage, demographics, and ART duration, dosing, and regimen. Results: Exposure to the SMS program was independently associated with greater prescription coverage (AOR = 1.23, 95% CI 1.13–1.34, P < 0.001) compared with non-exposure, although the absolute increase in prescription coverage was small (4.7 days of ART prescription coverage per average patient per year). Among a subset of patients (n = 725) whose pre-program prescription coverage was <100%, the corresponding mean expected absolute increase in prescription coverage was 8.2 days per year. Conclusions: Our primary finding was that an SMS reminder program implemented in routine clinical care was associated with a small increase in prescription coverage of uncertain clinical significance.en
dc.language.isoen_USen
dc.publisherBioMed Centralen
dc.relation.isversionofdoi:10.1186/s12911-017-0413-9en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC5319177/pdf/en
dash.licenseLAAen_US
dc.subjectHIVen
dc.subjectAntiretroviral therapyen
dc.subjectSouth Africaen
dc.subjectSMS programen
dc.subjectAdherenceen
dc.subjectDifferentiated careen
dc.subjectProgram evaluationen
dc.subjectImplementation researchen
dc.titleImpact of a clinical program using weekly Short Message Service (SMS) on antiretroviral therapy adherence support in South Africa: a retrospective cohort studyen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalBMC Medical Informatics and Decision Makingen
dash.depositing.authorGeorgette, Nathanen_US
dc.date.available2017-03-28T23:52:32Z
dc.identifier.doi10.1186/s12911-017-0413-9*
dash.contributor.affiliatedGeorgette, Nathan
dash.contributor.affiliatedZanoni, Brian
dash.contributor.affiliatedHaberer, Jessica
dash.contributor.affiliatedSiedner, Mark


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