Serum bilirubin levels and risk of type 2 diabetes: results from two independent cohorts in middle-aged and elderly Chinese

View/ Open
Author
Wang, Jing
Li, Yaru
Han, Xu
Hu, Hua
Wang, Fei
Li, Xiulou
Yang, Kun
Yuan, Jing
Yao, Ping
Miao, Xiaoping
Wei, Sheng
Wang, Youjie
Cheng, Weihong
Liang, Yuan
Zhang, Xiaomin
Guo, Huan
Yang, Handong
Yuan, Jianmin
Koh, Woon-Puay
Wu, Tangchun
Pan, An
He, Meian
Note: Order does not necessarily reflect citation order of authors.
Published Version
https://doi.org/10.1038/srep41338Metadata
Show full item recordCitation
Wang, J., Y. Li, X. Han, H. Hu, F. Wang, X. Li, K. Yang, et al. 2017. “Serum bilirubin levels and risk of type 2 diabetes: results from two independent cohorts in middle-aged and elderly Chinese.” Scientific Reports 7 (1): 41338. doi:10.1038/srep41338. http://dx.doi.org/10.1038/srep41338.Abstract
Serum bilirubin is a potent endogenous antioxidant and has been identified as cardiovascular risk in cohort studies, while the relation to type 2 diabetes (T2D) in the elderly remains unclear. We investigated both cross-sectional and prospective associations between serum bilirubin levels and T2D risk in the Dongfeng-Tongji (DFTJ) cohort, and replicated the prospective findings in a nested case-control study (509 cases and 509 controls) within the Singapore Chinese Health Study (SCHS). In the cross-sectional analysis of DFTJ cohort (15,575 participants with 2,532 diabetes cases), serum bilirubin levels (total, direct and indirect) increased in new on-set diabetes and decreased with the diabetic duration. In the longitudinal analysis of DFTJ cohort (772 incident diabetes cases during 4.5 years of follow-up among 12,530 diabetes-free participants at baseline), positive association was found between direct bilirubin and T2D risk comparing extreme quartiles, similar results were observed in the nested case-control study within SCHS. Total and indirect bilirubin levels were not significantly associated with T2D in either cohort. In conclusion, our findings do not support the protective association between serum bilirubin levels and incident T2D in the middle-aged and elderly adults; instead, direct bilirubin levels were associated with increased risk of T2D.Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5292699/pdf/Terms of Use
This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAACitable link to this page
http://nrs.harvard.edu/urn-3:HUL.InstRepos:31731891
Collections
- HMS Scholarly Articles [17714]
- SPH Scholarly Articles [6329]
Contact administrator regarding this item (to report mistakes or request changes)